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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Springer US

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DOI

10.1016/j.apm.2015.11.028

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1573-4919

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Increased synthesis of folate transporters regulat

Authors: Shilpa Thakur Deepti More Beenish Rahat Krishan Lal Khanduja Jyotdeep Kaur
Publish Date: 2015/10/03
Volume: 411, Issue: 1-2, Pages: 151-160
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Abstract

Excessive alcohol consumption and dietary folate inadequacy are the main contributors leading to folate deficiency FD The present study was planned to study regulation of folate transport in conditions of FD and ethanol exposure in human embryonic kidney cell line Also the reversible nature of effects mediated by ethanol exposure and FD was determined by folate repletion and ethanol removal For ethanol treatment HEK293 cells were grown in medium containing 100 mM ethanol and after treatment one group of cells was shifted on medium that was free from ethanol For FD treatment cells were grown in folatedeficient medium followed by shifting of one group of cells on folate containing medium FD as well as ethanol exposure resulted in an increase in folate uptake which was due to an increase in expression of folate transporters ie reduced folate carrier protoncoupled folate transporter and folate receptor both at the mRNA and protein level The effects mediated by ethanol exposure and FD were reversible on removal of treatment Promoter region methylation of folate transporters remained unaffected after FD and ethanol exposure As far as transcription rate of folate transporters is concerned an increase in rate of synthesis was observed in both ethanol exposure and FD conditions Additionally mRNA life of folate transporters was observed to be reduced by FD An increased expression of folate transporters under ethanol exposure and FD conditions can be attributed to enhanced rate of synthesis of folate transporters

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