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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Springer US

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DOI

10.1016/0038-1098(83)91050-5

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ISSN

1573-4919

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Ghrelin and obestatin expression in oral squamous

Authors: Manar M Alnema Suleyman Aydin Yusuf Ozkan Adile F Dagli Hanifi İ Ozercan Nezahat Yildirim İbrahim Sahin Aziz Karaoglu Nermin Kilic Mustafa Yilmaz Mehmet R Ozercan Emir Donder
Publish Date: 2010/01/03
Volume: 339, Issue: 1-2, Pages: 173-179
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Abstract

The underlying molecular mechanism of carcinogenesis in oral squamous cell carcinoma OSCC is poorly understood and appears to be controlled on many genetic environmental and hormonal factors Obestatin and ghrelin two recently discovered hormones are coexpressed in endocrine cells The purpose of this investigation was to examine the immunohistochemical features of OSCCs in relation to the tissue concentration of ghrelin and obestatin The association between OSCC and Epstein Barr Virus EBV status was also explored The expression of ghrelin and obestatin was examined by immunohistochemistry and immunoassay in oral biopsy specimens 10 benign squamous epithelial cell samples 10 microinvasive squamous cell carcinomas and seven welldifferentiated and seven poorly differentiated OSCCs The presence of EBV was evaluated in these samples using immunohistochemistry The concentrations of ghrelin and obestatin in tissue homogenates were measured by RIA and ELISA respectively Squamous cell carcinomas and benign tissue samples were positive for antiEBV antibody and obestatin and ghrelin were shown to be coexpressed in all stratified squamous epithelium samples Expression of ghrelin and obestatin was decreased or absent in OSCCs in relation to the invasiveness of the carcinoma ghrelin and obestatin levels in cancerous tissue homogenates were lower than in benign tissue homogenates These results indicate that the concentrations and distribution of immunoreactive obestatin and ghrelin might be helpful in distinguishing OSCC from benign tumors Maintaining normal levels of these hormones might be required for regulation of normal cell division However detailed studies will be required for better understanding of the complex mechanism of carcinogenesis relating to OSCCs

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