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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Springer US

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DOI

10.1016/0048-9697(96)05092-9

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ISSN

1573-4919

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Effects of tamoxifen on myocardial ischemiareperf

Authors: Rauf Onur Ek Yuksel Yildiz Serpil Cecen Cigdem Yenisey Tulay Kavak
Publish Date: 2007/11/03
Volume: 308, Issue: 1-2, Pages: 227-235
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Abstract

The purpose of this study is to examine the antiarrhythmic and antioxidant effects of tamoxifen one of the selective estrogen modulators in ovariectomized rats subjected to myocardial ischemiareperfusion I/R injury A month after ovariectomy rats were divided into four groups I ovariectomized controls without any treatment II ovariectomized rats treated with vehicle dimethylsulfoxide DMSO III–IV ovariectomized rats treated with tamoxifen 1 or 10 mg/kgsc daily for 14 days To produce arrhythmia the left main coronary artery was occluded for 7 min followed by 7 min of reperfusion The blood pressure BP heart rate HR electrocardiography ECG was recorded before and during the ischemiareperfusion period The blood levels of malondialdehyde MDA creatine kinase CK glutathione GSH glutathione peroxidase GSHPx glutathione reductase GR and catalase CAT were measured after the rats were killed Tamoxifen reduced the incidence of ventricular tachycardia VT on ischemia and reperfusion as well as the incidence and duration of reversible ventricular fibrillation VF on reperfusion I/R injury caused a significant fall in GSH GSHPx as well as an increase in MDA and CK levels in the control group when compared to tamoxifen treated groups The changes in levels of CAT and GR were however not significant In conclusion our findings suggest that tamoxifen has cardioprotective effects against I/R injury in rats likely its antioxidant properties

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