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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Springer US

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DOI

10.1016/0038-1101(81)90179-9

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ISSN

1573-4919

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Fatty acylation enhances cellular localization of

Authors: Richard W Dudley Brandon D Slotterbeck Marcia F McInerney Steven M Peseckis
Publish Date: 2010/10/08
Volume: 346, Issue: 1-2, Pages: 81-87
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Abstract

Two series of fluorescent molecules were synthesized by acylation of dansyl ethylenediamine and phenylalanine dansyl ethylenediamine with one of either acetyl C2 hexanyl C6 cyclohexanecarbonyl C7 myristyl C14 or palmityl C16 groups and examined for entry and localization in Chinese Hamster Ovary CHO cells in tissue culture Gross total fluorescence retention and cellular microscopic fluorescence patterns were analyzed In both series molecules with myristyl or palmityl groups entered cells Only in the phenylalanine series did hexyl and cyclohexanecarbonyl modification enable entry Consistent with a mechanism of passive diffusion entry of compounds into cells was neither energy dependent nor endocytosis linked Acylated molecules were observed to localize in cytoplasm and not enter nuclei or associate with lipophilic plasma membranes

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