Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Mol Cell Biochem

Search In Journal Title:

Abbravation: Molecular and Cellular Biochemistry

Search In Journal Abbravation:

Publisher

Springer US

Search In Publisher:

DOI

10.1016/0025-3227(67)90096-5

Search In DOI:

ISSN

1573-4919

Search In ISSN:
Search In Title Of Papers:

Role of SIRT1 in Emphasis Type="Italic"Streptoco

Authors: Li Lin Shunhang Wen Shuzhen Guo Xiaoyan Su Hujun Wu Lei Chong Hailin Zhang Weixi Zhang Changchong Li
Publish Date: 2014/06/04
Volume: 394, Issue: 1-2, Pages: 199-208
PDF Link

Abstract

Streptococcus pneumoniae is an important pathogen of pneumonia in human Human alveolar epithelium acts as an effective barrier and is an active participant in host defense against invasion of bacterial by production of various mediators Sirtuin 1 SIRT1 the prototypic class III histone deacetylase is involved in the molecular control of lifespans and immune responses This study aimed at examining the role of SIRT1 in mediating S pneumoniaeinduced human βdefensin2 hBD2 and interleukin8IL8 expression in the alveolar epithelial cell line A549 and the underlying mechanisms involved A549 cells were infected with S pneumoniae for indicated times Exposure of A549 cells to S pneumoniae increased the expressions of SIRT1 protein hBD2 and IL8 mRNA and protein The SIRT1 activator resveratrol enhanced S pneumoniaeinduced gene expression of hBD2 but decreased IL8 mRNA levels Blockade of SIRT1 activity by the SIRT1 inhibitors nicotinamide reduced S pneumoniaeinduced hBD2 mRNA expression but increased its stimulatory effects on IL8 mRNA S pneumoniaeinduced activation of extracellular signalregulated kinase ERK and p38 mitogenactivated protein kinase MAPK SIRT1 expression was attenuated by selective inhibitors of ERK and p38 MAPK The hBD2 mRNA production was decreased by pretreatment with p38 MAPK inhibitor but not with ERK inhibitor whereas the IL8 mRNA expression was controlled by phosphorylation of ERK These results suggest that SIRT1 mediates the induction of hBD2 and IL8 gene expression levels in A549 cell by S pneumoniae SIRT1 may play a key role in host immune and defense response in A549This study was supported by grants from the National Natural Science Foundation of China No 30973232 the Provincial Natural Science Foundation of Zhejiang No Z13H010003 and the Clinical Key Discipline in Pediatric Respiratory Disease of National Health and Family Planning Commission of the People’s Republic of ChinaNo 20130209 and Scientific Research Fund of Zhejiang Provincial Education Department No Y201432837

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Hepatitis B virus replication causes oxidative stress in HepAD38 liver cells
  2. 4-(4-Chloro-2-methylphenoxy)- N -hydroxybutanamide (CMH) targets mRNA of the c-FLIP variants and induces apoptosis in MCF-7 human breast cancer cells
  3. Glycyrrhizin ameliorates metabolic syndrome-induced liver damage in experimental rat model
  4. Retinol-binding protein 4 as a risk factor for cholesterol gallstone formation
  5. FoxO1 signaling plays a pivotal role in the cardiac telomere biology responses to calorie restriction
  6. Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer
  7. Calorie restriction increases telomerase activity, enhances autophagy, and improves diastolic dysfunction in diabetic rat hearts
  8. The synergistic induction of cyclooxygenase-2 in lung fibroblasts by angiotensin II and pro-inflammatory cytokines
  9. Fatty acylation enhances cellular localization of dansylated phenylalanines
  10. Tetramerization of SATB1 is essential for regulating of gene expression
  11. Retraction Note to: Adipose stromal-vascular fraction-derived paracrine factors regulate adipogenesis
  12. The molecular interaction of a copper chelate with human P-glycoprotein
  13. Zinc stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation
  14. Ciprofloxacin as a potential radio-sensitizer to tumor cells and a radio-protectant for normal cells: differential effects on γ-H2AX formation, p53 phosphorylation, Bcl-2 production, and cell death
  15. Inhibition of p90 ribosomal S6 kinase attenuates cell migration and proliferation of the human lung adenocarcinoma through phospho-GSK-3β and osteopontin
  16. Increased antitumor capability of fiber-modified adenoviral vector armed with TRAIL against bladder cancers
  17. Hormonal imbalance and disturbances in carbohydrate metabolism associated with chronic feeding of high sucrose low magnesium diet in weanling male wistar rats
  18. Silencing SATB1 inhibits proliferation of human osteosarcoma U2OS cells
  19. Epigenetics in anoxia tolerance: a role for histone deacetylases
  20. Characterization of a multidrug-resistant chronic myeloid leukemia cell line presenting multiple resistance mechanisms
  21. Increased synthesis of folate transporters regulates folate transport in conditions of ethanol exposure and folate deficiency
  22. Apollon/Bruce is upregulated by Humanin
  23. Inhibitory effect of anti-aminopeptidase N/CD13 antibodies on fibroblast migration
  24. Pin1 modulates chemo-resistance by up-regulating FoxM1 and the involvements of Wnt/β-catenin signaling pathway in cervical cancer
  25. Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators
  26. Glutathione S -transferase M1, T1, and P1 genotypes and breast cancer risk: a study in a Portuguese population
  27. Quercitrin a bioflavonoid improves the antioxidant status in streptozotocin: induced diabetic rat tissues
  28. Induction of Fas-mediated extrinsic apoptosis, p21WAF1-related G2/M cell cycle arrest and ROS generation by costunolide in estrogen receptor-negative breast cancer cells, MDA-MB-231
  29. Ω3-Polyunsaturated fatty acids prevent lipoperoxidation, modulate antioxidant enzymes, and reduce lipid content but do not alter glycogen metabolism in the livers of diabetic rats fed on a high fat thermolyzed diet
  30. Expression and analysis of two novel rat organic cation transporter homologs, SLC22A17 and SLC22A23
  31. Betulinic acid inhibits the expression of hypoxia-inducible factor 1α and vascular endothelial growth factor in human endometrial adenocarcinoma cells
  32. Macrophage migration inhibitory factor does not modulate co-activation of androgen receptor by Jab1/CSN5
  33. Growth and sex effects on the expression of syndecan-4 and glypican-1 in turkey myogenic satellite cell populations
  34. Bioinformatic and biochemical studies point to AAGR-1 as the ortholog of human acid α-glucosidase in Caenorhabditis elegans
  35. Suppression of NF-κB and IRF-1-induced transcription of the murine IL-12 p40 by transforming growth factor-β Smad pathway in macrophages
  36. Exon array analysis reveals genetic heterogeneity in atypical femoral fractures. A pilot study
  37. Manganese supplementation increases adiponectin and lowers ICAM-1 and creatinine blood levels in Zucker type 2 diabetic rats, and downregulates ICAM-1 by upregulating adiponectin multimerization protein (DsbA-L) in endothelial cells
  38. Troxerutin reverses fibrotic changes in the myocardium of high-fat high-fructose diet-fed mice
  39. Antagonizing canonical Wnt signaling pathway by recombinant human sFRP4 purified from E. coli and its implications in cancer therapy
  40. Glycine- and proline-rich glycoprotein regulates the balance between cell proliferation and apoptosis for ACF formation in 1,2-dimethylhydrazine-treated A/J mice
  41. Cell surface interaction of annexin A2 and galectin-3 modulates epidermal growth factor receptor signaling in Her-2 negative breast cancer cells
  42. Nanoceria protects from alterations in oxidative metabolism and calcium overloads induced by TNFα and cycloheximide in U937 cells: pharmacological potential of nanoparticles
  43. Ghrelin and obestatin expression in oral squamous cell carcinoma: an immunohistochemical and biochemical study
  44. CNTF-ACM promotes mitochondrial respiration and oxidative stress in cortical neurons through upregulating L-type calcium channel activity
  45. Low ethanol intake prevents salt-induced hypertension in WKY rats
  46. miR-202 suppresses proliferation and induces apoptosis of osteosarcoma cells by downregulating Gli2
  47. Screening of chemopreventive effect of naringenin-loaded nanoparticles in DMBA-induced hamster buccal pouch carcinogenesis by FT-IR spectroscopy
  48. Effects of tamoxifen on myocardial ischemia-reperfusion injury model in ovariectomized rats
  49. Muscle regeneration occurs to coincide with mitochondrial biogenesis
  50. Lung cancer risk in north Indian population: role of genetic polymorphisms and smoking
  51. Troxerutin suppresses lipid abnormalities in the heart of high-fat–high-fructose diet-fed mice
  52. Erratum to: A comparative study of glycoproteomes in androgen-sensitive and -independent prostate cancer cell lines
  53. Diazoxide-induced respiratory inhibition – a putative mitochondrial K ATP channel independent mechanism of pharmacological preconditioning
  54. Upregulation of Glyoxalase I fails to Normalize Methylglyoxal Levels: A Possible Mechanism for Biochemical Changes in Diabetic Mouse Lenses
  55. The dependence of enhanced lysosomal activity on the cellular aging of bovine aortic endothelial cells
  56. Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin
  57. Oxidant/antioxidant effects of chronic exposure to predator odor in prefrontal cortex, amygdala, and hypothalamus
  58. Phosphorylation of translation factors in response to anoxia in turtles, Trachemys scripta elegans: role of the AMP-activated protein kinase and target of rapamycin signalling pathways
  59. Smad2 protects against TGF-β1/Smad3-mediated collagen synthesis in human hepatic stellate cells during hepatic fibrosis
  60. Insulin ameliorates miR-1-induced injury in H9c2 cells under oxidative stress via Akt activation
  61. The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor
  62. Enteroaggregative Escherichia coli infection induces IL-8 production via activation of mitogen-activated protein kinases and the transcription factors NF-κB and AP-1 in INT-407 cells
  63. Lupeol and its ester inhibit alteration of myocardial permeability in cyclophosphamide administered rats
  64. RC3/neurogranin negatively regulates extracellular signal-regulated kinase pathway through its interaction with Ras
  65. Oxidant/anti-oxidant dynamics in patients with advanced cervical cancer: correlation with treatment response
  66. Quaternary structural parameters of the congenital cataract causing mutants of αA-crystallin
  67. Interleukin-6 as possible early marker of stress response after femoral fracture
  68. Improvement of cerebral function by anti-amyloid precursor protein antibody infusion after traumatic brain injury in rats
  69. C-reactive protein augments hypoxia-induced apoptosis through mitochondrion-dependent pathway in cardiac myocytes
  70. AP4 activates cell migration and EMT mediated by p53 in MDA-MB-231 breast carcinoma cells
  71. Antimetastatic potential of fisetin involves inactivation of the PI3K/Akt and JNK signaling pathways with downregulation of MMP-2/9 expressions in prostate cancer PC-3 cells
Search Result: