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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Publisher

Springer US

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DOI

10.1007/bf01049024

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ISSN

1573-4919

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Interleukin6 as possible early marker of stress r

Authors: Goran Pesic Jovana Jeremic Tamara Nikolic Vladimir Zivkovic Ivan Srejovic Aleksandra Vranic Jovana Bradic Branko Ristic Aleksandar Matic Nikola Prodanovic Vladimir Jakovljevic
Publish Date: 2017/02/16
Volume: 430, Issue: 1-2, Pages: 191-199
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Abstract

Bone fracture healing is a complex process which at best results in full recovery of function and structure of injured bone tissue but all the mechanisms involved in this process and their mutual interaction are not fully understood Despite advancement of surgical procedures this type of fractures is still a major public health concern In the last few decades a lot of attention is focused on the oxygenfree radicals and inflammatory response markers as important factors of skeletal injury Thus the aim of the present study was to follow the changes in redox balance and inflammatory response in elderly patients with femoral fractures during the earliest stages of fracture healing by measuring the values of the observed markers immediately after fracture as well as the first third and seventh postoperative day Present study was performed on a group of 65 elderly patients with femoral neck fractures recruited from the Orthopedic Clinic Clinical Centre Kragujevac in the period from February to May 2015 Redox status was measured spectrophotometrically and evaluated by measuring the levels of index of lipid peroxidation measured as TBARS nitrite NO2 − superoxide anion radical O2 − and hydrogen peroxide H2O2 in plasma while activities of corresponding antioxidative enzymes catalase CAT superoxide dismutase SOD and reduced glutathione GSH were measured in erythrocytes The cytokine concentrations of interleukin IL6 and tumor necrosis factor TNFα were determined in plasma using ELISA assays specific for human cytokines Our study showed that redox status and TNFα in elderly patients with femoral fractures did not show statistically significant changes during the early phase of fracture healing On the other hand IL6 increased statistically in first day after intervention This preliminary study has shown our observations and we hope that these results may help in better understanding mechanisms which are included at fracture healing More importantly this study attempted to create a platform for further research

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