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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Springer US

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DOI

10.1002/pssb.2220650224

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1573-4919

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The synergistic induction of cyclooxygenase2 in l

Authors: Takaya Matsuzuka Kathryn Miller Lara Pickel Chiyo Doi Rie Ayuzawa Masaaki Tamura
Publish Date: 2008/10/01
Volume: 320, Issue: 1-2, Pages: 163-171
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Abstract

Although we have demonstrated that Angiotensin II Ang II signaling plays a role in colon and lung tumorigenesis the precise mechanisms by which Ang II stimulates tumorigenesis remain unclear The aim of this study was to investigate the synergistic induction of COX2 by Ang II and proinflammatory cytokines in lung fibroblasts We also compared the efficiencies of Ang IIdependent COX2 induction in lung epithelial cells and stromal cells Ang II induced COX2 expression in lung fibroblasts in a dosedependent manner 10−9 to 10−7 M through the Ang II subtype 1 receptor AT1 In addition Ang II synergistically stimulated the induction of COX2 by proinflammatory cytokines IL1β or TNFα Our results indicate that the protumorigenic function of Ang II is attributable in part to its strong stimulatory effect of COX2 expression in lung fibroblasts in which synergistic stimulation with proinflammatory cytokines was evident It is also suggested that the AT1 receptor in lung fibroblasts may be a rational target for chemoprevention of lung cancerThe authors thank Dr Dharmendra Maurya Ms Jennifer Reischman and Marla Pyle Department of Anatomy Physiology Kansas State University Manhattan KS for critical reading and constructive comments during the preparation of the manuscript This work was supported in part by Kansas State University KSU Terry C Johnson Center for Basic Cancer Research KSU Provost’s fund KSU College of Veterinary Medicine Dean’s fund NIH grant P20 RR017686

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