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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Publisher

Springer US

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DOI

10.1007/978-1-349-13992-7_2

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ISSN

1573-4919

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The dependence of enhanced lysosomal activity on t

Authors: Jihee Yoon KiJu Kim YoungWoo Choi Hwa Sung Shin YangHoon Kim Jiho Min
Publish Date: 2010/02/20
Volume: 340, Issue: 1-2, Pages: 175-178
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Abstract

Lysosomes are a cell organelle type processing antimicrobial activity Here we investigate the lysosomal activity in a primary cell line bovine aortic endothelial cells BAECs during cellular aging based on the antimicrobial activity of lysosomes isolated from BAECs at cell passages 4 6 8 and 10 Cytochemical analysis of lysosomes with LysoTracker reagent revealed the number of lysosomelike organelles surrounding the nucleus initially increased drastically in the BAECs and continued increasing gradually until passage 10 The lysosomes isolated from each successive passage of BAECs exhibited increased antimicrobial activity against Escherichia coli and in addition an agedependent increase in lysosome intensity coincided with increased lysosomal antimicrobial activity

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