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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Springer US

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DOI

10.1007/s11771-016-3107-z

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ISSN

1573-4919

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Oxidant/antioxidant dynamics in patients with adv

Authors: Alpana Sharma Medha Rajappa Abhigyan Satyam Manoj Sharma
Publish Date: 2010/03/31
Volume: 341, Issue: 1-2, Pages: 65-72
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Abstract

Cervical cancer is the most common cancer in Indian women Oxidative stress is potentially harmful to cells and ROS are involved in multistage carcinogenesis in initiation and promotion The aim was to study the alterations in the circulating pro/antioxidants in advanced cervical cancer patients before and after neoadjuvant chemoradiation and to assess the relevance of the variation in the levels to therapeutic response 90 patients with advanced cancer cervix FIGO IIIaIVa and 90 healthy controls were enrolled Blood samples were collected before and after chemotherapy after radiation and after 1 year on followup Pro/antioxidant levels were estimated using standard methods Response to therapy was assessed during and after therapy and after 1 year of followup The pretreatment levels of plasma lipid peroxide were significantly elevated while antioxidant levels were lowered in cancer patients when compared to controls After chemotherapy lipid peroxidation showed a significant decline in complete responders as compared with partial/nonresponders and remained highly significant after therapy and during followup Antioxidant enzymes showed a mild increase P  005 after chemotherapy in complete responders as compared with partial/nonresponders and remained highly significant after therapy and on followup This important finding suggests that pretreatment levels of antioxidant–oxidant parameters and the extent of their change during treatment can predict the therapeutic response to neoadjuvant chemoradiation in advanced cancer cervix Oxidant–antioxidant profile merits investigation as markers of response survival and recurrence in larger prospective studies which might throw light on their possible use as predictors of chemoradiosensitivity of cervical tumors

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