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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Springer US

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DOI

10.1016/0014-2999(84)90265-6

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ISSN

1573-4919

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Screening of chemopreventive effect of naringenin

Authors: N Krishnakumar N K Sulfikkarali S Manoharan R Madhavan Nirmal
Publish Date: 2013/06/09
Volume: 382, Issue: 1-2, Pages: 27-36
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Abstract

The aim of the present study is to investigate the chemopreventive effects of the prepared naringeninloaded nanoparticles NARNPs relative to efficacy of free naringenin NAR in modifying the functional structural and compositional changes at the molecular level during 7 12dimethylbenzaanthracene DMBAinduced hamster buccal pouch HBP carcinogenesis by Fourier transform infrared FTIR spectroscopy The results revealed that a significant increase in the amount of proteins and nucleic acid contents and a decrease in the amount of lipids and glycogen contents are observed in DMBAinduced tumor tissues In addition in tumor tissues a decrease in lipid order and a significant increase in membrane dynamics were noticed Further the composition and secondary structure of proteins were found to be altered which indicates some important structural alterations in the existing proteins and/or the expression of new types of proteins occurring under the tumor transformation Furthermore oral administration of free NAR and NARNPs significantly increased lipids and their order as well as increased the glycogen contents and decreased the levels of proteins and nucleic acid contents On a comparative basis NARNPs were found to have a more potent antitumor effect than free NAR in completely preventing the formation of squamous cell carcinoma and in improving the biochemical constituents to a normal range in DMBAinduced HBP carcinogenesis The present study further shows a great potential of FTIR spectroscopy as a complimentary tool for the screening of various anticancer drugs and followup which may allow faster response to critical problems arising during treatment

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