Authors: Zhengwen Sun Tongqing Zhang Huanyu Hong Qingxia Liu Haiguang Zhang
Publish Date: 2014/08/26
Volume: 397, Issue: 1-2, Pages: 277-283
Abstract
Accumulating data have shown that microRNAs are involved in the pathogenesis of cancer miR202 has been confirmed to be downregulated in several types of human cancer However the expression and biological role of miR202 in osteosarcoma OS carcinogenesis and progression remain unclear In this study we demonstrated that miR202 expression is significantly decreased in human OS cell lines and specimens Restoration of miR202 expression could inhibit OS cell proliferation induce cell apoptosis and suppress tumor growth in nude mice models We subsequently identified the transcription factor Gli2 as a direct target of miR202 Overexpression of Gli2 blocked the inhibitory function of miR202 Taken together our results indicate that miR202 acts as a novel tumor suppressor to regulate OS cell proliferation and apoptosis through downregulating Gli2 expression
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