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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Kluwer Academic Publishers-Plenum Publishers

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DOI

10.1006/mpev.2000.0896

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1573-4919

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Lupeol and its ester inhibit alteration of myocard

Authors: Periyasamy Thandavan Sudharsan Yenjerla Mythili Elangovan Selvakumar Palaninathan Varalakshmi
Publish Date: 2006/09/29
Volume: 292, Issue: 1-2, Pages: 39-44
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Abstract

Cyclophosphamide CP an alkylating agent widely used in cancer chemotherapy causes cardiac membrane damage Lupeol a pentacyclic triterpene isolated from Crataeva nurvala stem bark and its ester lupeol linoleate possess a wide range of medicinal properties The effect of lupeol and its ester was evaluated in CP induced alterations in cardiac electrolytes in rats Male albino rats of Wistar strain were categorized into 6 groups Group I served as control Rats in groups II V and VI were injected intraperitoneally with a single dose of CP 200 mg/kg body weight dissolved in saline CP treated groups V and VI received lupeol and lupeol linoleate 50 mg/kg body weight respectively dissolved in olive oil for 10 days by oral gavage At the end of the experimental period urinary risk factors activities of ATPases and electrolytes were measured using standard procedures CP administered rats showed a significant decrease P 0001 in the activities of ATPases It was associated with significant alterations P 0001 of electrolytes both in serum and cardiac tissue The levels of urea uric acid and creatinine were also significantly P 0001 altered in the serum and urine Lupeol and its ester showed reversal of the above alterations induced by CP These findings demonstrate that the supplementation with lupeol and its ester could preserve membrane permeability highlighting their protective effect against CP induced cardiotoxicity

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