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Title of Journal: Mol Cell Biochem

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Abbravation: Molecular and Cellular Biochemistry

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Springer US

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DOI

10.1007/s00066-004-1294-2

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1573-4919

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Muscle regeneration occurs to coincide with mitoch

Authors: Akira Wagatsuma Naoki Kotake Shigeru Yamada
Publish Date: 2010/11/26
Volume: 349, Issue: 1-2, Pages: 139-147
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Abstract

We investigated the expression of the nuclearencoded genes controlling the mitochondrial properties in the mouse gastrocnemius muscle to gain insight into the mitochondrial biogenesis that occurs during the muscle degeneration/regeneration induced by freezing In addition we tested whether the muscle regeneration is affected by pharmacologically blocking the mitochondrial protein synthesis to elucidate the possible involvement of mitochondrial biogenesis in muscle regeneration The activity of citrate synthase dramatically increased soon after the initial injury when the myoblasts began to differentiate into myotubes indicating that mitochondrial biogenesis occurs early during the muscle regeneration At the same time the expression of mitochondrial biogenesisrelated genes including PGC1β PRC NRF1 NRF2 TFAM mtSSB fission 1 and Lon protease synchronized with that of the myogenic regulatory genes including MyoD and myogenin The skeletal muscles forced to regenerate in the presence of chloramphenicol to block the mitochondrial protein synthesis were of poor repair with small myofibers and an increased amount of connective tissue These results suggest that mitochondrial biogenesis activated early during the muscle regeneration and that mitochondrial biogenesis plays a role in muscle regeneration

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