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Title of Journal: Biotechnol Lett

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Abbravation: Biotechnology Letters

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Springer Netherlands

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DOI

10.1016/0091-3057(88)90358-9

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1573-6776

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Taxolinduced alteration of intracellular aminoac

Authors: XiaoFei Han YanQiu Liu LongXing Wang QianXu Yang HongBin Xiao
Publish Date: 2011/09/22
Volume: 34, Issue: 1, Pages: 1-7
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Abstract

The antitumor action of Taxol was investigated in the changes of aminoacids involved in tumor cell survival By tracing the intracellular aminoacid profiles of HeLa cells treated with nonconditioned and three conditioned media Taxol lalanine and Taxol + lalanine it was observed that an alteration of aminoacid metabolism participates in Taxolinduced death of HeLa cells The contents of 18 out of 21 detected aminoacids are 5–95 and the ones of lysine and methionine are 158 and 117 of the corresponding contents in the control after treatment with Taxol for 24 h respectively Addition of lalanine inhibited cell apoptosis upon Taxol treatment by partially blocking the increase of lysine and methionine and reversing decrease trend of alanine glycine and glutamic acid These results suggest that interference of aminoacid metabolism might be an important mechanism of Taxol cytotoxicity

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