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Title of Journal: Biotechnol Lett

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Abbravation: Biotechnology Letters

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Springer Netherlands

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DOI

10.1016/0167-4870(90)90020-a

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1573-6776

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Porcine testicular extract inhibits T cell prolife

Authors: HanHyoung Lee Suk Jun Lee Sunhee Kim Seonah Jeong Manheum Na DongMok Lee YongPil Cheon Ki Ho Lee Inho Choi Taehoon Chun
Publish Date: 2012/03/29
Volume: 34, Issue: 7, Pages: 1225-1233
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Abstract

Since T cells express diverse sex steroid hormone receptors they might be a good model to evaluate the effects of sex steroid hormones on immune modulation Porcine testicular extract contains several sex steroid hormones and may be useful to study the effects of sex steroid hormones during T cell activation We have examined the effects of the porcine testicular extract on T cell activation proliferation and secretion of cytokines IL2 and IFNγ by activated T cells were severely decreased after treatment with porcine testicular extract The extract produced an immunosuppressive effect and inhibited the proliferation of activated T cells by blocking the cell cycle transition from the G1 phase to S phase These effects were mediated by a decrease in the expression of cyclin D1 and cyclin E and constitutive expression of p27KIP1 after T cell activationThis study was supported by Technology Development Program for Agriculture and Forestry project number 1080893 Ministry for Agriculture Forestry and Fisheries Republic of Korea and NextGeneration BioGreen 21 program No PJ008089 Rural Development Administration Republic of Korea

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