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Title of Journal: Biotechnol Lett

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Abbravation: Biotechnology Letters

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Springer Netherlands

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DOI

10.1016/0266-3538(90)90011-s

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1573-6776

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Electrospun silk fibroin mat enhances tendonbone

Authors: Yunlong Zhi Wen Liu Peng Zhang Jia Jiang Shiyi Chen
Publish Date: 2016/06/27
Volume: 38, Issue: 10, Pages: 1827-1835
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Abstract

Rabbit bone marrowderived mesenchymal stem cells proliferated well on electrospun SF mat The autologous Achilles tendon wrapped with electrospun SF mat was transplanted into the bone tunnel experimental group in a rabbit extraarticular model while the unwrapped tendon was transplanted as control group The electrospun SF mat wrapping could enhance tendonbone healing of autologous tendon evaluated by microcomputed tomography scanning histological examination and mechanical testing At 6 and 12 weeks postoperatively the failure loads of experimental group were both significantly higher than those of control group 405 ± 63 vs 318 ± 46 N P = 0039 at 6 weeks 671 ± 9 vs 522 ± 47 N P = 0012 at 12 weeks

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