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Title of Journal: Eur Radiol

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Abbravation: European Radiology

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Springer-Verlag

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DOI

10.1016/j.arcped.2012.04.020

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1432-1084

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Transarterial chemoembolization alone and in combi

Authors: A Maataoui J Qian D Vossoughi M F Khan E Oppermann W O Bechstein T J Vogl
Publish Date: 2004/12/04
Volume: 15, Issue: 1, Pages: 127-133
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Abstract

The purpose of this study is to compare transarterial chemoembolization TACE alone and in combination with other therapies in an animal model Subcapsular implantation of a solid Morris hepatoma 3924A in the liver was carried out in 50 male ACI rats day 0 Tumor volume V1 was measured by MRI day 13 After laparotomy and retrograde placement of a catheter into the gastroduodenal artery day 14 the following protocols of the interventional procedure were applied TACE mitomycin C + lipiodol + immunotherapy group A TNFα + IL2 group B OK432 + IL2 TACE + antiangiogenesis therapy group C TNP470 group D endostatin TACE alone in group E control group Tumor volume V2 was assessed by MRI and the mean ratio of x V2/V1 was calculated Data were analyzed using Dunnett’s t test comparing therapeutic groups with the control group and the StudentNewmanKeuls test comparing significant therapeutic groups Multivariate analysis showed a significant reduction in the tumor growth rate P005 in groups B x=653 and C x=401 compared to the mean ratio of the control group E x=914 Significant results were observed in group C P005 in comparison with the other therapeutic groups TACE combined with immunotherapy OK432 and antiangiogenesis therapy TNP470 retards tumor growth compared with TACE alone in an HCC animal model

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