Authors: Kishore Rajendran Caroline Löbker Benjamin S Schon Christopher J Bateman Raja Aamir Younis Niels J A de Ruiter Alex I Chernoglazov Mohsen Ramyar Gary J Hooper Anthony P H Butler Tim B F Woodfield Nigel G Anderson
Publish Date: 2016/05/10
Volume: 27, Issue: 1, Pages: 384-392
Abstract
We incubated a 25mm strip of excised osteoarthritic human tibial plateau in 50 ionic iodine contrast and imaged it using a smallanimal spectral scanner with a cadmium telluride photonprocessing detector to quantify the iodine through the thickness of the articular cartilage We imaged both spectroscopic phantoms and osteoarthritic tibial plateau samples The iodine distribution as an inverse marker of GAG content was presented in the form of 2D and 3D images after applying a basis material decomposition technique to separate iodine in cartilage from bone We compared this result with a histological section stained for GAGThe iodine in cartilage could be distinguished from subchondral bone and quantified using multienergy CT The articular cartilage showed variation in iodine concentration throughout its thickness which appeared to be inversely related to GAG distribution observed in histological sections
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