Authors: Florian N Fleckenstein Rüdiger E Schernthaner Rafael Duran Jae Ho Sohn Sonia Sahu Yan Zhao Bernd Hamm Bernhard Gebauer MingDe Lin JeanFrançois Geschwind Julius Chapiro
Publish Date: 2016/01/13
Volume: 26, Issue: 9, Pages: 3243-3252
Abstract
This retrospective analysis included 122 patients A quantitative 3D analysis was performed on baseline MRI to calculate enhancing tumour volume ETV cm3 and enhancing tumour burden ETB ratio between ETV cm3 and liver volume Furthermore enhancing and overall tumour diameters were measured Patients were stratified into two groups using thresholds derived from the BCLC staging system Statistical analysis included Kaplan–Meier plots uni and multivariate cox proportional hazard ratios HR and concordancesAll methods achieved good separation of the survival curves p 005 Multivariate analysis showed an HR of 52 95 CI 31–88 p 0001 for ETV cm3 and HR 66 95 CI 37–115 p 0001 for ETB vs HR 26 95 CI 12–56 p = 0012 for overall diameter and HR 30 95 CI 15–63 p = 0003 for enhancing diameter Concordances were highest for ETB with no added predictive power for multilesion assessment difference between concordances not significant
Keywords: