Authors: Salvatore Nigro Gennarina Arabia Angelo Antonini Luca Weis Andrea Marcante Alessandro Tessitore Mario Cirillo Gioacchino Tedeschi Stefano Zanigni Giovanna CalandraBuonaura Caterina Tonon Gianni Pezzoli Roberto Cilia Mario Zappia Alessandra Nicoletti Calogero Edoardo Cicero Michele Tinazzi Pierluigi Tocco Nicolò Cardobi Aldo Quattrone
Publish Date: 2016/10/19
Volume: 27, Issue: 6, Pages: 2665-2675
Abstract
To investigate the reliability of a new inhouse automatic algorithm for calculating the Magnetic Resonance Parkinsonism Index MRPI in a large multicentre study population of patients affected by progressive supranuclear palsy PSP or Parkinson’s disease PD and healthy controls HC and to compare the diagnostic accuracy of the automatic and manual MRPI valuesThe study included 88 PSP patients 234 PD patients and 117 controls MRI was performed using both 3T and 15T scanners Automatic and manual MRPI values were evaluated and accuracy of both methods in distinguishing PSP from PD and controls was calculatedNo statistical differences were found between automated and manual MRPI values in all groups The automatic MRPI values differentiated PSP from PD with an accuracy of 95 manual MRPI accuracy 96 and 97 manual MRPI accuracy 100 for 15T and 3T scanners respectively
Keywords: