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Title of Journal: Eur Radiol

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Abbravation: European Radiology

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Springer Berlin Heidelberg

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DOI

10.1016/j.bbrc.2015.07.098

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1432-1084

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Multimodality imaging assessment of the deleteriou

Authors: Alain Nchimi Audrey Courtois Mounia El Hachemi Ziad Touat Pierre Drion Nadia Withofs Geoff Warnock MohamedAli Bahri JeanMichel Dogné JeanPaul CheramyBien Laurent Schoysman Julien Joskin JeanBaptiste Michel JeanOlivier Defraigne Alain Plenevaux Natzi Sakalihasan
Publish Date: 2015/09/22
Volume: 26, Issue: 7, Pages: 2378-2386
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Abstract

The postinduction growth of the AAA diameter was characterized using ultrasound in 22 rats ILT was reported on 13 rats that underwent 14 magnetic resonance imaging MRI 218 days postsurgery and on 10 rats that underwent 18 fluorodeoxyglucose FDG positron emission tomography PET/microcomputed tomography examinations 227 days postsurgery Logistic regressions were used to establish the evolution with time of AAA length diameter ILT thickness volume stratification MRI and FDG PET signalling properties and histological assessment of inflammatory infiltratesAll of the following significantly increased with time postinduction p 0001 AAA length AAA diameter ILT maximal thickness ILT volume ILT iron content and related MRI signalling changes quantitative uptake on FDG PET and the magnitude of inflammatory infiltrates on histology However the aneurysm growth peak followed occurrence of ILT approximately 6 days after elastase infusionThe authors thank Mrs Cécile Wegria and Carmela La Mantia for manuscript handling editing and management Jacques Trentesaux JeanMarc Léonard and JeanFrançois Monville MD for their kind assistance and advice in MRI The scientific guarantor of this publication is Natzi Sakalihasan MD PhD The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article This study has received funding by the 7th European Framework Program collaborative project Fighting Aneurysmal Disease FAD Adelin Albert PhD and Laurence Seidel PhD kindly provided statistical advice for this manuscript Institutional Review Board approval was obtained Approval from the institutional animal care committee was obtained Methodology prospective experimental performed at one institution

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