Authors: J Walldorf M Hermann M Porzner S Pohl H Metz K Mäder A Zipprich B Christ T Seufferlein
Publish Date: 2015/05/17
Volume: 25, Issue: 10, Pages: 2984-2991
Abstract
Determination of colon wall thickness using hrUS 32 MHz and measurement of the crosssectional colonic areas by btMRI allowed discrimination between the treatment groups mean a vs b vs c – btMRI 922 vs 2051 vs 1472 pixel hrUS 026 vs 045 vs 031 mm btMRI endoscopy hrUS and colour DopplerhrUS correlated to histological scoring p 005 while endoscopy and btMRI correlated to postmortem colon length p 005The innovative in vivo techniques btMRI and hrUS are safe and technically feasible They differentiate between distinct grades of colitis in an experimental setting and correlate with established postmortem parameters In addition to endoscopic procedures these techniques provide information regarding colon wall thickness and perfusion Depending on the availability of these techniques their application increases the value of in vivo monitoring in experimental acute colitis in small rodentsThe scientific guarantor of this publication is Jens Walldorf The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article The authors state that this work has not received any funding No complex statistical methods were necessary for this paper Institutional Review Board approval was not required because no studies on humans were performed Approval from the institutional animal care committee was obtained Methodology experimental performed at one institution
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