Authors: Hediye Pınar Gunbey Meltem Ceyhan Bilgici Kerim Aslan Arzu Ceylan Has Methiye Gonul Ogur Aslıhan Alhan Lutfi Incesu
Publish Date: 2016/10/31
Volume: 27, Issue: 7, Pages: 3013-3021
Abstract
Ten children with DS and eight healthy control subjects were included in the study Tractbased spatial statistics TBSS were used in the DTI study for wholebrain voxelwise analysis of fractional anisotropy FA and mean diffusivity MD of WM Volumetric analyses were performed with an automated segmentation method to obtain regional measurements of cortical volumesChildren with DS showed significantly reduced FA in association tracts of the frontotemporooccipital regions as well as the corpus callosum CC and anterior limb of the internal capsule p 005 Volumetric reductions included total cortical GM cerebellar GM and WM volume basal ganglia thalamus brainstem and CC in DS compared with controls p 005These preliminary results suggest that DTI and volumetric analyses may reflect the earliest complementary changes of the neurodevelopmental delay in children with DS and can serve as surrogate biomarkers of the specific elements of WM and GM integrity for cognitive developmentThis paper was presented as an oral presentation at ECR 2016 The scientific guarantor of this publication is Hediye Pınar Gunbey The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article The authors state that this work has not received any funding Aslıhan Alhan kindly provided statistical advice for this manuscript Institutional Review Board approval was obtained Written informed consent was obtained from all subjects patients in this study Methodology prospective crosssectional study performed at one institution
Keywords: