Authors: Francesca Martino Mariya Malova Claudia Cesaretti Cecilia Parazzini Chiara Doneda Luca A Ramenghi Andrea Rossi Andrea Righini
Publish Date: 2015/10/16
Volume: 26, Issue: 8, Pages: 2685-2696
Abstract
Prenatal features of isolated cerebellar haemorrhagic lesions have not been sufficiently characterised We aimed to better define their MR imaging characteristics documenting the location extension evolution stage and anatomic sequelae and to better understand cerebellar haemorrhage pathophysiologyWe screened our foetal MR imaging database 3200 cases for reports of haemorrhagic lesions affecting only the cerebellum without any supratentorial bleeding or other clastic lesions defined as one of the following T2weighted hypointense or mixed hypo/hyperintense signal rim of T2weighted hypointense signal covering the surface of volumereduced parenchyma T1weighted hyperintense signal increased DWI signalSeventeen cases corresponded to the selection criteria All lesions occurred before the 26th week of gestation with prevalent origin from the peripheralcaudal portion of the hemispheres and equal frequency of unilateral/bilateral involvement The caudal vermis appeared affected in 2/3 of cases not in all cases confirmed postnatally Lesions evolved towards malformed cerebellar foliation The aetiology and pathophysiology were unknown although in a subset of cases intra and extracranial venous engorgement seemed to play a key roleThe scientific guarantor of this publication is Andrea Righini MD The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article The authors state that this work has not received any funding No complex statistical methods were necessary for this article Institutional Review Board approval was not required because this retrospective study complied with internal clinical review study guidelines in use in our institution Written informed consent was not required for this study because all mothers signed a disclosure form allowing their clinical data to be used for clinical retrospective research Methodology retrospective observational singlecentre study
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