Authors: N G Anderson A P Butler N J A Scott N J Cook J S Butzer N Schleich M Firsching R Grasset N de Ruiter M Campbell P H Butler
Publish Date: 2010/03/23
Volume: 20, Issue: 9, Pages: 2126-2134
Abstract
We developed a desktop spectral CT dubbed MARS based around the Medipix2 photoncounting energydiscriminating detector The single conventional Xray tube operated at constant voltage 75 kVp and constant current 150 µA We anaesthetised with ketamine six black mice C57BL/6 We introduced iodinated contrast material and barium sulphate into the vascular system alimentary tract and respiratory tract as we euthanised them The mice were preserved in resin and imaged at four detector energy levels from 12 keV to 42 keV to include the Kedges of iodine 330 keV and barium 374 keV Principal component analysis was applied to reconstructed images to identify components with independent energy response then displayed in 2D and 3DWe thank the Medipix2 and Medipix3 collaborations and European Organisation for Nuclear Research CERN for use of the Medipix detectors Graeme Kershaw for fixing the mice in the resin Judith Dawson for help preparing the manuscript Steffi Girst for dose estimation
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