Authors: Matthias König Eva Bültmann Lucas BodeSchnurbus Dirk Koenen Eckhart Mielke Lothar Heuser
Publish Date: 2006/05/16
Volume: 17, Issue: 1, Pages: 39-47
Abstract
The purpose of this study was to evaluate the impact of various iodine contrast concentrations on image quality in computed tomography CT perfusion studies Twentyone patients with suspicion of cerebral ischemia underwent perfusion CT using two different iodine contrast concentrations 11 patients received iomeprol 300 iodine concentration 300 mg/ml while ten received the same volume of iomeprol 400 iodine concentration 400 mg/ml Scan parameters were kept constant for both groups Maps of cerebral blood flow CBF cerebral blood volume CBV and time to peak TTP were calculated from two adjacent slices Quantitative comparisons were based on measurements of the maximum enhancement Hounsfield units HU and signaltonoise index SNI on CBF CBV and TTP images Determinations of greytowhitematter delineation for each iodine concentration were performed by two blinded readers Only data from the nonischemic hemispheres were considered Both maximum enhancement and SNI values were higher after iomeprol 400 resulting in significantly better image quality in areas of low perfusion No noteworthy differences were found for normal values of CBF CBV and TTP Qualitative assessment of grey/white matter contrast on CBF and CBV maps revealed better performance for iomeprol 400 For brain perfusion studies highly concentrated contrast media such as iomeprol 400 is superior to iomeprol 300
Keywords: