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Title of Journal: Eur Radiol

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Abbravation: European Radiology

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Springer Berlin Heidelberg

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DOI

10.1016/0010-4361(92)90190-6

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1432-1084

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Amide Proton Transfer APT MR imaging and Magneti

Authors: Hong Zhang Huiying Kang Xuna Zhao Shanshan Jiang Yi Zhang Jinyuan Zhou Yun Peng
Publish Date: 2016/01/13
Volume: 26, Issue: 10, Pages: 3368-3376
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Abstract

Eightytwo neurodevelopmentally normal children 44 males and 38 females age range 2−190 months were imaged using an APT/MT imaging protocol with multiple saturation frequency offsets The APTweighted APTW and MT ratio MTR signals were quantitatively analyzed in multiple brain areas Agerelated changes in MTR and APTW were evaluated with a nonlinear regression analysisThe APTW signals followed a decreasing exponential curve with age in all brain regions measured R2 = 07−08 for the corpus callosum frontal and occipital white matter and centrum semiovale The most significant changes appeared within the first year At maturation larger decreases in APTW and lower APTW values were found in the white matter On the contrary the MTR signals followed an increasing exponential curve with age in the same brain regions measured with the most significant changes appearing within the initial 2 years There was an inverse correlation between the MTR and APTW signal intensities during brain maturation

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