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Title of Journal: Eur Radiol

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Abbravation: European Radiology

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Springer Berlin Heidelberg

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DOI

10.1002/ange.19640761629

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ISSN

1432-1084

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Reduced white matter integrity and cognitive defic

Authors: Ruijie Zhang Kai Liu Linfeng Yang Tao Zhou Shaowen Qian Bo Li Zhaohui Peng Min Li Shengpeng Sang Qingjun Jiang Gang Sun
Publish Date: 2014/10/18
Volume: 25, Issue: 3, Pages: 661-668
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Abstract

Twentysix maintenance hemodialysis ESRD patients and 28 healthy controls underwent diffusion tensor imaging DTI Mini Mental State Examination MMSE Trial Marking TestAB TMTAB and white matter hyperintensity WMH assessment Tractbased spatial statistics TBSS analyses was performed to evaluate WM changes in the patients Relationships between behavioural performances clinical data and the DTI index were tested respectively by correlation analysis at the voxel levelESRD patients showed significant decreased fractional anisotropy FA in 14 WM regions and increased mean diffusivity MD and radial diffusivity RD in widespread regions Significant positive correlations between FA values and MMSE scores were found in the right anterior corona radiata and the left anterior thalamic radiation significant negative correlations between the TMTB time consumption and FA values were identified in the bilateral superior longitudinal fasciculus Positive linear relationships between MD RD values and the duration of hemodialysis were found in several WM regions

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