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Title of Journal: Dig Dis Sci

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Abbravation: Digestive Diseases and Sciences

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Springer US

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DOI

10.1002/anie.199719151

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1573-2568

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Phytic Acid Modulates In Vitro IL8 and IL6 Relea

Authors: Ludmiła Węglarz Joanna Wawszczyk Arkadiusz Orchel Marzena JaworskaKik Zofia Dzierżewicz
Publish Date: 2006/12/12
Volume: 52, Issue: 1, Pages: 93-102
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Abstract

Phytic acid PA a major fiberassociated component of wheat bran and legumes is physiologically present in the human large gut The aim of this study was to examine the role of PA in immunologic function of intestinal epithelial cells by analyzing its effect on interleukin IL8 and IL6 secretion by colonocytes and its role in the response of these cells to bacterial lipopolysaccharides LPS and IL1β The human colon cell line Caco2 was exposed to LPS isolated from two strains of Desulfovibrio desulfuricans wild intestinal and type soil strains as well as to LPS from E coli Cells were also treated with IL1β and with a combination of LPS and IL1β PA had a suppressive effect on IL8 basal release and it dose dependently reduced IL8 secretion by colonocytes stimulated with LPS and IL1β On the contrary PA increased constitutive IL6 secretion and exhibited differentiated effects on LPS responsiveness of cells depending on its concentration and LPS origin PA was also an efficient downregulator of IL6 secretion stimulated by binary actions of LPS and IL1β The ability of PA to modulate IL8 and IL6 release suggests that PA present in the intestinal milieu may exert immunoregulatory effects on colonic epithelium under physiological conditions or during microbeinduced infection/inflammation in order to maintain the colonic mucosa in a noninflammatory state or to counteract infection

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