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Title of Journal: Dig Dis Sci

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Abbravation: Digestive Diseases and Sciences

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Springer US

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DOI

10.1016/0167-9317(90)90067-4

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1573-2568

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Atorvastatin Does Not Improve Liver Biochemistries

Authors: Carmen M Stanca Nancy Bach Jorge Allina Carol Bodian Henry Bodenheimer Joseph A Odin
Publish Date: 2008/04/05
Volume: 53, Issue: 7, Pages: 1988-1993
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Abstract

Statin treatment reduces hypercholesterolemia and may be antiinflammatory Case reports noted decreased alkaline phosphatase and histological improvement following statin treatment in primary biliary cirrhosis The objective of this study was to assess the longterm effects of statin treatment in primary biliary cirrhosis A retrospective analysis compared clinical and biochemical data from 15 hypercholesterolemic individuals with primary biliary cirrhosis who were treated longterm with atorvastatin with an age and gender matched primary biliary cirrhosis control group A significant decrease in total cholesterol and lowdensity lipoprotein LDLcholesterol p ≤ 0002 was observed throughout atorvastatin treatment median time 25 years LDLcholesterol levels in the control group were not significantly changed after 2 years p  0050 No significant changes were noted in alanine aminotransferase ALT alkaline phosphatase total bilirubin and Mayo Risk Score in either group p  005 Longterm atorvastatin treatment reduced LDLcholesterol in primary biliary cirrhosis but there was no evidence of any antiinflammatory effectThe authors would like to thank Donald Smith MD Thomas D Schiano MD and Samuel Sigal MD for clinical and editorial advice and Greg Bach and Colin Quinn for assistance in data collection This project was funded by a grant from the Artzt Family PBC Charitable Trust Mount Sinai Division of Liver Diseases and an NIH grant DK59653 JAO

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