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Title of Journal: Dig Dis Sci

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Abbravation: Digestive Diseases and Sciences

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Springer US

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DOI

10.1002/9780470682104.ch5

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1573-2568

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A MetaAnalysis of Nucleostide Analogues in Pati

Authors: Yingnan Huang Hao Wu Shengdi Wu Da Fu Yushui Ma Xizhong Shen
Publish Date: 2012/09/30
Volume: 58, Issue: 3, Pages: 815-823
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Abstract

An online search within PubMed Web of Science Embase Cochrane Central of Register of Controlled Trials and China Biology Medicine disc from 19980101 to 20110905 was conducted A metaanalysis was performed Relative risks of mortality rate ChildPughTurcotte score and hepatitis B eantigen HBeAg seroconversion of the decompensated patients were studiedEight studies involving 511 patients were included Data showed that lamivudine and telbivudine significantly decreased the mortality rate relative risk 036 95  confidence interval 025–054 improved the ChildPughTurcotte scores mean difference −323 95  confidence interval −398 to −248 and promoted HBeAg seroconversion relative risk 748 95  confidence interval 231–2420The authors would like to thank the members of Prof Xizhong Shen’s Laboratory for their helpful discussion and critical reading of the manuscript The study was partly funded by the Major National Science and Technology Projects 2009ZX10004301 2008ZX10002017 Shanghai Science and Technology Commission 10410709400 10411950100 Shanghai Talent Development Foundation 2009035 National Nature Science Foundation of China 30872503 81000968 81101540 and 81172273 The National Clinical Key Special Subject of China Nature Science Foundation of Shanghai 12ZR1436000 and the Youth Innovation Promotion Association Chinese Academy of Sciences

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