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Title of Journal: Dig Dis Sci

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Abbravation: Digestive Diseases and Sciences

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Springer US

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DOI

10.1007/s11873-013-0221-z

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1573-2568

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A High Level of TM4SF5 Is Associated with Human Es

Authors: Yongbing Wu Yousheng Huang Yaping Xu Yufang Sun Dongliang Yu Xiaoqiang Zhang Xiang Long Shuqiang Zhu Jiangliang Zhou Jianjun Xu
Publish Date: 2013/04/30
Volume: 58, Issue: 9, Pages: 2623-2633
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Abstract

We analyzed TM4SF5 expression in normal esophageal epithelial cells HEEC in four HEC cell lines and in 20 HEC clinical tissue samples and matched nontumor samples The effect of TM4SF5 on HEC cell proliferation and metastasis and invasion was assessed and the relationship between TM4SF5 and integrin β1 was determined Finally TM4SF5 and integrin β1 expression were further examined by use of immunohistochemistry IHC and tissue microarray analysis and the prognostic use of TM4SF5 and integrin β1 in HEC was evaluatedTM4SF5 was more highly expressed in HEC cells and in HEC tissues than in HEEC and matched nontumor tissues Downregulation of TM4SF5 in KYSE150 cells reduced cell proliferation and metastasis and invasion whereas metastasis and invasion by KYSE510 increased after TM4SF5 cDNA transfection In HEC cells TM4SF5 formed a complex with integrin β1 and interference with integrin β1 in KYSE510TM4SF5 cells markedly inhibited cell invasion on laminin 5 Our findings also showed that TM4SF5 and integrin β1 overexpression correlated with low differentiation and high stage p  005 respectively Postoperative 5year overall survival of patients with TM4SF5low and/or integrin β1low was higher than for patients with TM4SF5high and/or integrin β1high Multivariate analysis demonstrated that TM4SF5 and integrin β1 cooverexpression was an independent prognostic marker for HEC

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