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Title of Journal: Dig Dis Sci

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Abbravation: Digestive Diseases and Sciences

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Springer US

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DOI

10.1007/s00266-013-0070-z

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1573-2568

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Predictors of Colorectal Cancer Following a Negati

Authors: Amanpal Singh YongFang Kuo Taylor S Riall G S Raju James S Goodwin
Publish Date: 2011/06/17
Volume: 56, Issue: 11, Pages: 3122-3128
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Abstract

A 5 national sample of Medicare enrollees from 1996 to 2005 was used to identify patients undergoing complete colonoscopy A colonoscopy not associated with any procedure eg biopsy polypectomy or fulguration was defined as a negative colonoscopy Patients with history of inflammatory bowel disease colorectal cancer or death within 12 months of colonoscopy were excluded A multivariable model was constructed to evaluate the factors associated with a new diagnosis of colorectal cancer in the period from 12 to 120 months following the negative colonoscopyAmong 200857 patients mean age 74 years 61 female 92 White with a negative colonoscopy the incidence of colorectal cancer was 18 per 1000 personyears The incidence rate for matched followup periods decreased from 20/1000 personyears for patients undergoing colonoscopy during 1996–2000 to 12/1000 person years during 2001–2005 Multivariate analysis revealed a significant regional variation in the incidence of colorectal cancer following a negative colonoscopy The incidence was higher in patients 85 years males and patients who underwent a negative colonoscopy by a nongastroenterologist or endoscopist in the lowest volume quartile On stratified analyses endoscopist volume was a significant predictor for nongastroenterologists only

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