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Title of Journal: Dig Dis Sci

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Abbravation: Digestive Diseases and Sciences

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Springer US

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DOI

10.1007/bf02769266

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ISSN

1573-2568

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Evaluation of a Noninvasive Method to Detect Cyto

Authors: Hans H Herfarth Millie D Long Tara C Rubinas Mikki Sandridge Melissa B Miller
Publish Date: 2010/02/18
Volume: 55, Issue: 4, Pages: 1053-1058
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Abstract

A severe flare of colitis in patients with IBD treated with immunosuppressive therapy may be complicated by an underlying CMV infection The aim of this pilot study was to investigate the diagnostic efficacy of quantitative polymerase chain reaction PCR to detect CMV DNA in stool samples of IBD patientsTwentyone patients with a severe flare of IBD incompletely responding or refractory to either steroids or immunosuppressive agents were included in the study Nineteen patients completed the study according to the protocol undergoing an endoscopy with biopsies and collection of stool samples Biopsy and stool samples were qualitatively and quantitatively analyzed for CMV DNA using realtime PCRThirtytwo percent 6/19 of the patients had detectable CMV DNA in colonic biopsies and in five 83 of those patients CMV DNA was detected in the stool Thirteen patients had negative findings for CMV DNA in biopsy and stool samples The sensitivity specificity and accuracy of the PCRbased stool test for detection of CMV DNA compared to PCRbased detection of CMV in mucosal biopsies were 83 93 and 90 respectivelyThe pilot study suggests a high accuracy of this noninvasive testing method to detect CMV DNA in stool samples as compared to mucosal biopsies This approach may offer a nonendoscopic testing modality for underlying CMV infection in patients with a severe flare of IBD which could also be applied more broadly to determine the prevalence of CMV infections in patients with IBD

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