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Title of Journal: Dig Dis Sci

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Abbravation: Digestive Diseases and Sciences

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Springer US

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DOI

10.1002/nme.1620190802

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1573-2568

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Increased Numbers of Circulating ICOSSuperscript

Authors: Li Wang Xiguang Sun Jinpeng Qiu Yanjun Cai Liang Ma Pingwei Zhao Yanfang Jiang
Publish Date: 2014/11/18
Volume: 60, Issue: 2, Pages: 405-413
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Abstract

The numbers of circulating CD27+ CD38+ CD86+ and CD95+ B cells as well as inducible T cell costimulator ICOS+ and programmed death1 PD1+ IL21+ TFH cells were examined in 58 patients with newly diagnosed PBC and 30 matched healthy controls HCsThe numbers of circulating CD38+CD19+ CD86+CD19+ and CD95+CD19+ B cells CD3+CD4+CXCR5+ICOS+ and CD3+CD4+CXCR5+PD1+ Tfh cells and the levels of serum IL21 in the PBC patients were significantly greater but the numbers of CD27+CD19+ B cells were significantly less than those in the HCs p  005 The numbers of CD3+CD4+CXCR5+ICOS+ Tfh cells were positively correlated with the numbers of CD38+CD19+ and CD86+CD38+CD19+ B cells and the levels of serum antimitochondrial antibodies against M2 antigen AMAM2 AMA and immunolgubin M IgM in the PBC patients The levels of serum IL21 were positively correlated with the levels of serum AMAM2 AMA IgG and IgM but negatively with the numbers of CD27+CD19+ B cells in the PBC patientsSupported by grants from the National Natural Science Foundation of China no 30972610 and 81273240 Jilin Province Science and Technology Agency no 20110716 the Health Department Research Projects in Jilin Province 2009Z054 and Norman Bethune Program of Jilin University 2012206

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