Authors: Tomomitsu Tahara Tomiyasu Arisawa Fangyu Wang Tomoyuki Shibata Masakatsu Nakamura Mikijyu Sakata Ichiro Hirata Hiroshi Nakano
Publish Date: 2007/10/13
Volume: 53, Issue: 4, Pages: 919-924
Abstract
Tolllike receptors TLRs play important roles in the signaling of many pathogenrelated molecules and endogenous proteins associated with immune activation −196 to −174del polymorphism affects the TLR2 gene and alters its promoter activity We investigated the influence of TLR2 −196 to −174del polymorphism on the risk of gastroduodenal diseases on the severity of Helicobacter pyloriinduced gastritis in a Japanesepopulation The study was performed on 309 patients with abdominal discomfort and 146 healthy controls −196 to −174del polymorphism of TLR2 was investigated by allelespecific polymerase chain reaction method in all of the subjects Gastritis scores of antral gastric mucosa were assessed according to the updated Sydney system in H pyloripositive subjects n = 156 Patients with abdominal discomfort was consisted of 80 gastric ulcers 259 38 duodenal ulcers 123 five gastric + duodenal ulcers 16 105 patients with gastritis 340 and 81 normal healthy stomachs 262 We did not find any association between TLR2 polymorphism and risk of gastric ulcer duodenal ulcer gastric and duodenal ulcer and gastritis compared to healthy controls However the TLR2−196 to −174ins allele was associated with severity of intestinal metaplasia in more than 60 years of ages P = 002 The same allele also increased the risks of developing more severe gastric mucosal atrophy and intestinal metaplasia in female subjects P 005 P = 007 respectively No association was observed between TLR2 polymorphism and severity of neutrophil and mononuclear cell infiltration Our data suggest that the TLR2−196 to −174ins allele was associated with more severe intestinal metaplasia in patients older than was correlated with severity of gastric mucosal atrophy and intestinal metaplasia in female subjects
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