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Title of Journal: Dig Dis Sci

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Abbravation: Digestive Diseases and Sciences

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Springer US

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DOI

10.1007/978-3-0348-7001-6_4

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1573-2568

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A MetaAnalysis of Antibiotic Therapy for Active U

Authors: Roja Rahimi Shekoufeh Nikfar Ali Rezaie Mohammad Abdollahi
Publish Date: 2007/04/06
Volume: 52, Issue: 11, Pages: 2920-2925
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Abstract

To systematically evaluate the efficacy of antibacterial therapy in ulcerative colitis we carried out a metaanalysis of controlled clinical trials Within the time period 1966 through September 2006 PUBMED EMBASE and SCOPUS were searched for clinical trial studies that investigated the efficacy of antibiotics in ulcerative colitis We considered clinical remission as our key outcome of interest Of 122 studies 10 randomized placebocontrolled clinical trials matched our criteria and were included in the analysis 530 patients All the studies used antibiotics as an adjunct therapy to conventional treatment of ulcerative colitis ie corticosteroids and 5aminosalycilic acid Pooling of these trials yielded odds ratio OR of 214 95 confidence interval CI 148–309 P00001 in favor of antimicrobial therapy Metaanalysis of shortterm trials 5–14 days showed a higher rate of clinical remission in patients treated with antibiotics OR 202 95 CI 136–3 These results suggest that adjunctive antibacterial therapy is effective for induction of clinical remission in ulcerative colitis

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  2. Response to Peginterferon-alfa 2b and Ribavirin in Japanese Patients with Chronic Hepatitis C Genotype 2
  3. Correlations of C-reactive Protein Levels and Erythrocyte Sedimentation Rates with Endoscopic Activity Indices in Patients with Ulcerative Colitis
  4. Preprocedural Rabeprazole Treatment Before Endoscopic Submucosal Dissection for Gastric Neoplasms
  5. Do We Need Multiple Biopsies for Assessing Gastric Cancer Risk?
  6. The Pathogenesis of Eosinophilic Esophagitis: Beyond the Eosinophil
  7. Disease Behavior in Children with Crohn’s Disease: The Effect of Disease Duration, Ethnicity, Genotype, and Phenotype
  8. Triggering for Submaximal Exercise Level in Gastric Exercise Tonometry: Serial Lactate, Heart Rate, or Respiratory Quotient?
  9. The Correlation Between the Subsets of Tumor Infiltrating Memory T Cells and the Expression of Indoleamine 2,3-Dioxygenase in Gastric Cancer
  10. Bacterial Translocation to Mesenteric Lymph Nodes Increases in Chronic Portal Hypertensive Rats
  11. Narrow-Banding Images and Structures of Microvessels of Colonic Lesions
  12. Inflammatory Bowel Disease: A Patient’s and Caregiver’s Perspective
  13. Atorvastatin Does Not Improve Liver Biochemistries or Mayo Risk Score in Primary Biliary Cirrhosis
  14. Effective Intra-Esophageal Acid Control Is Associated with Improved Radiofrequency Ablation Outcomes in Barrett’s Esophagus
  15. Effective Intra-Esophageal Acid Control Is Associated with Improved Radiofrequency Ablation Outcomes in Barrett’s Esophagus
  16. The Risk of Colorectal Cancer in Patients with Ulcerative Colitis
  17. Needle Size Has Only a Limited Effect on Outcomes in EUS-Guided Fine Needle Aspiration: A Systematic Review and Meta-Analysis
  18. Are the Echogenicities on Intraductal Ultrasonography Really Biliary Microlithiasis?
  19. The Role of Chromoendoscopy in the Surveillance of the Duodenum of Patients with Familial Adenomatous Polyposis
  20. Gene Expression Profile Analysis of the Spontaneous Reversal of Rat Hepatic Fibrosis by cDNA Microarray
  21. Toll-like Receptor 2 (TLR) −196 to 174del Polymorphism in Gastro-duodenal Diseases in Japanese Population
  22. Bifidobacterial Diversity Determined by Culturing and by 16S rDNA Sequence Analysis in Feces and Mucosa from Ten Healthy Spanish Adults
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  26. Proximal and Overall Gastric Emptying of Solids in Patients with Reduced Gastric Volume Accommodation Compared to Matched Controls
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  30. A High Level of TM4SF5 Is Associated with Human Esophageal Cancer Progression and Poor Patient Survival
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  42. Phytic Acid Modulates In Vitro IL-8 and IL-6 Release from Colonic Epithelial Cells Stimulated with LPS and IL-1β
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