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Title of Journal: Dig Dis Sci

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Abbravation: Digestive Diseases and Sciences

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Springer US

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DOI

10.1007/bf00177057

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1573-2568

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The Role of Hepatic Ischemia–Reperfusion Injury an

Authors: Lorenzo A Orci Stéphanie Lacotte Graziano Oldani Philippe Morel Gilles Mentha Christian Toso
Publish Date: 2014/05/03
Volume: 59, Issue: 9, Pages: 2058-2068
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Abstract

Hepatic ischemia/reperfusion I/R injury is a common clinical challenge Despite accumulating evidence regarding its mechanisms and potential therapeutic approaches hepatic I/R is still a leading cause of organ dysfunction morbidity and resource utilization especially in those patients with underlying parenchymal abnormalities In the oncological setting there are growing concerns regarding the deleterious impact of I/R injury on the risk of postsurgical tumor recurrence This review aims at giving the last updates regarding the role of hepatic I/R and liver parenchymal quality injury in the setting of oncological liver surgery using a “benchtobedside” approach Relevant medical literature was identified by searching PubMed and hand scanning of the reference lists of articles considered for inclusion Numerous preclinical models have depicted the impact of I/R injury and hepatic parenchymal quality steatosis age on increased cancer growth in the injured liver Putative pathophysiological mechanisms linking I/R injury and liver cancer recurrence include an increased implantation of circulating cancer cells in the ischemic liver and the upregulation of proliferation and angiogenic factors following the ischemic insult Although limited there is growing clinical evidence that I/R injury and liver quality are associated with the risk of postsurgical cancer recurrence In conclusion on top of its harmful early impact on organ function I/R injury is linked to increased tumor growth Therapeutic strategies tackling I/R injury could not only improve postsurgical organ function but also allow a reduction in the risk of cancer recurrenceWe are grateful to Mrs Dawne Colwell for her precious input in graphic design This study was supported by the Ligue genevoise contre le cancer the Henri DuboisFerrière/Dinu Lipatti Foundation and the Artères Foundation Lorenzo Orci and Christian Toso were supported by the Swiss National Science Foundation Grants 323530151477 3232230126233

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