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Title of Journal: Dig Dis Sci

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Abbravation: Digestive Diseases and Sciences

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Springer US

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DOI

10.1016/0048-9697(81)90181-9

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1573-2568

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Preprocedural Rabeprazole Treatment Before Endosco

Authors: Myong Ki Baeg MyungGyu Choi Seong Jin Moon ChulHyun Lim Jin Su Kim Yu Kyung Cho Jae Myung Park In Seok Lee Sang Woo Kim Kyu Yong Choi
Publish Date: 2014/03/27
Volume: 59, Issue: 9, Pages: 2243-2248
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Abstract

This was a prospective randomized controlled trial Patients were administered oral rabeprazole 20 mg or placebo twice daily for 5 days before ESD Intravenous pantoprazole 40 mg was administered 2 h before ESD and at postprocedure day 1 and then oral rabeprazole 20 mg was administered once daily Followup endoscopy was performed on days 1 and 30 Fortyeighthour measurement of intragastric pH was performed in 26 patients The primary endpoint was major bleeding related to ESDOnehundred and twenty patients were enrolled Of these 45 in the pretreatment and 53 in the placebo group were analyzed Each group had three cases of major bleeding There were no significant differences in the ulcer healing rate Intragastric pH percentage times greater than 4 5 and 6 were 8661 ± 1945  8330 ± 2206  and 7686 ± 2535  respectively in the pretreatment and 8554 ± 1945  8408 ± 2711  and 8153 ± 2781  respectively in the placebo group without significant differences

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