Authors: Qin Xu Wei Zhang Tianyi Zhang Ruijie Zhang Yanfang Zhao Yuan Zhang Yibin Guo Rui Wang Xiuqiang Ma Jia He
Publish Date: 2016/03/18
Volume: 61, Issue: 7, Pages: 1986-1995
Abstract
That obesity leads to gastroesophageal reflux is a widespread notion However scientific evidence for this association is limited with no rigorous epidemiological approach conducted to address this question This study examined the relationship between body mass index BMI and gastroesophageal reflux symptoms in a large populationrepresentative sample from ChinaWe performed a crosssectional study in an age and genderstratified random sample of the population of five central regions in China Participants aged 18–80 years completed a general information questionnaire and a Chinese version of the Reflux Disease Questionnaire The zeroinflated Poisson regression model estimated the relationship between body mass index and gastroesophageal reflux symptomsOverall 16091 894 of the 18000 eligible participants responded 638 397 and 1738 1081 experienced at least weekly heartburn and weekly acid regurgitation respectively After adjusting for potential risk factors in the zeroinflated part the frequency odds ratio OR 066 95 confidence interval 95 CI 050–086 p = 0002 and severity OR 066 95 CI 050–088 p = 0004 of heartburn in obese participants were statistically significant compared to those in normal participants In the Poisson part the frequency of acid regurgitation overweight OR 110 95 CI 101–121 p = 0038 and obesity OR 119 95 CI 104–137 p = 0013 were statistically significant BMI was strongly and positively related to the frequency and severity of gastroesophageal reflux symptoms Additionally gender exerted strong specific effects on the relationship between BMI and gastroesophageal reflux symptomsQin Xu Wei Zhang Yibin Guo and Tianyi Zhang have provided contributions in interpreting the data drafting the manuscript and approved the final draft submitted Ruijie Zhang Yanfang Zhao Yuan Zhang and Rui Wang have provided substantial contributions in planning and conducting the study Xiuqiang Ma and Jia He provided substantial contributions in planning and conducting the study and approved the final draft All authors reviewed the manuscript and agreed on the final versionSupported by the fund of the Fourth Round of Threeyear Action Plan on Public Health Discipline and Talent Program EvidenceBased Public Health and Health Economics No 15GWZK0901 the Key Program of Shanghai Soft Science Research No 14692101700 three grants from the Ministry of Science and Technology of China 2012ZX10002010 2012ZX09303011002 and 2012ZX09303001001 the leading talents of science in Shanghai 2010 022
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