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Title of Journal: Dig Dis Sci

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Abbravation: Digestive Diseases and Sciences

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Springer US

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ISSN

1573-2568

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Aryl Hydrocarbon Receptor Activation DownRegulate

Authors: Tao Ji Chao Xu Lihua Sun Min Yu Ke Peng Yuan Qiu Weidong Xiao Hua Yang
Publish Date: 2015/03/24
Volume: 60, Issue: 7, Pages: 1958-1966
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Abstract

The pathogenesis of inflammatory bowel disease IBD is associated with dysregulation of intestinal immune system Aryl hydrocarbon receptor AHR is believed to control the chronic inflammation in the gut Besides interleukin7 IL7 is proved to be an important cytokine that activates mucosal inflammation in IBD Moreover intraepithelial lymphocytes IELs are one of the key immunological compartments involved in regulating intestinal inflammation In this study we investigated the function of 6formylindolo 32b carbazole Ficz a ligand of AHR on IL7 colitis and IEL phenotypesColitis was induced by administration of dextran sulfate sodium DSS to wildtype C57BL/6J mice for 7 days Mice were weighted colon tissues were collected and measured and histology analyses were performed IELs were isolated from colon and the phenotype and activation of IELs were examined using flow cytometry detection The expression of AHR and IL7 was measured by immunofluorescence Western blot and RTPCRFicz downregulated epithelialderived IL7 expression in mice with DSSinduced colitis and ameliorated DSSinduced colitis Ficz also decreased CD8αβ+ and CD8+ IEL subpopulations enhanced TCRγδ+ IEL subpopulation and reduced the percentage of activated CD4+ and CD8+ subpopulationsFicz could downregulate epithelialderived IL7 expression in mice with DSSinduced colitis and inhibit inflammation in the gastrointestinal tract of mice AHRrelated compounds might be the new and promising therapeutic medicaments for the treatment of patients with IBDThis research was supported by grants from the National Natural Science Foundation of China NSFC 81330013 and NSFC 81272078 to HY NSFC 81200288 to WSW NSFC 81270451 to WDX and the Program of Changjiang Scholars and Innovative Research IRT 13050 to HY

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