Authors: Aasma Shaukat Mustafa Arain Bharat Thaygarajan John H Bond Mandeep Sawhney
Publish Date: 2010/03/19
Volume: 55, Issue: 8, Pages: 2352-2356
Abstract
Colon cancers diagnosed in the interval after a complete colonoscopy may occur due to limitations of colonoscopy or due to rapid tumor growth The aim of this study was to compare the association of BRAF V600E mutation in interval versus noninterval colorectal cancers and to determine the relationship between BRAF mutation and 5year survivalWe searched our institution’s cancer registry for interval cancers defined as colon cancers that developed within 5 years of a complete colonoscopy These were frequency matched to patients with noninterval cancers Archived cancer specimens were tested for BRAF V600E mutation and MSIThere were 63 interval and 131 noninterval cancers BRAF mutation was present in 28 of interval cancers compared to 19 of noninterval cancers P = 018 In a multivariable logistic regression model proximal location OR 185 95 CI 101–38 and MSI OR 27 95 11–68 were independently associated with interval cancers while BRAF mutation was not OR 093 95 CI 036–238 BRAF mutation portended a poor 5year survival particularly among microsatellite stable cancers
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