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Title of Journal: Dig Dis Sci

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Abbravation: Digestive Diseases and Sciences

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Springer US

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DOI

10.1002/pfi.4170310610

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1573-2568

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Circulating Methylated Emphasis Type="Italic"MIN

Authors: Jing Han Ping Lv JiangLiu Yu YiChen Wu Xin Zhu LianLian Hong WangYu Zhu QiMing Yu XinBao Wang Pei Li ZhiQiang Ling
Publish Date: 2014/01/03
Volume: 59, Issue: 6, Pages: 1160-1168
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Abstract

Aberrant DNA methylation has been shown to be associated with the growth development metastasis and prognosis of tumors Methylated DNAs may be suitable biomarkers for cancer patients Here we investigated whether circulating methylated MINT2 DNAs represent a potential poor prognostic factor in gastric cancer GCMINT2 methylation was detected by realtime methylationspecific PCR in tumor tissues pairing preoperative peritoneal lavage fluid PPLF and blood from 92 GC patients The theory meaning and clinical practicality value of MINT2 methylation in different specimens were analyzedThe methylation status of the MINT2 gene was found to be significantly higher in tumor tissues 446  41/92 than in adjacent normal tissues 33  3/92 No MINT2 methylation was found in healthy controls and partial MINT2 methylation was observed in three 625  3/48 patients with chronic atrophic gastritis The frequency of MINT2 methylation in pairing PPLF and blood samples from 92 GC patients was 402  37/92 and 391  36/92 respectively Methylated MINT2 in tumor tissues pairing PPLF and blood samples were very approximate Aberrant MINT2 methylation in tumor tissues and pairing PPLF or blood samples were closely related to peritoneal dissemination tumor progression and poor prognosis all P  00001This research was supported by a grant from the program for New Century Excellent Talents in University from the Ministry of Education China NCET110949 a grant from the Science and Technology General Project of Zhejiang Province No 2009C33143 Key Research Projects of Medicine from the Ministry of Health China No WKJ20102004 partly by a grant from the Backbone Talent of Zhejiang Provincial Medicine and Hygiene Platform Programs No 2011RCA009 a grant from the Scientific and Technological Innovations Fund of Henan Province Higher Education No 2009HAST1T001 and by a grant from the Science and Technology Key Project of the Ministry of Education China No 210130

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