Authors: Ron Shaoul Amir Karban Shimon Reif Batia Weiss Raanan Shamir Ada Tamir Ofir Davidovich Jonathan Halevi Esther Leshinsky Silver Arie Levine
Publish Date: 2008/07/02
Volume: 54, Issue: 1, Pages: 142-150
Abstract
Background Disease behavior in Crohn’s disease CD may be modified by disease location and genotype Disease behavior may change over time and thus analysis requires followup To date there have been few pediatric studies that have evaluated the association between disease behavior and genotype with prolonged followup The aim of our study was to evaluate the effect of genotype phenotype and ethnicity on disease behavior in pediatric CD Methods Evaluation of 128 pediatric CD was followed by analysis of 232 pediatric and adultonset CD patients Inclusion required at least 2 years of followup Phenotype ethnicity and disease duration were recorded Patients were genotyped for polymorphisms in the NOD2/CARD15 gene Results Colonic involvement was more frequent in younger patients Pediatric disease at end of followup was classified as inflammatory 78 penetrating 7 and stricturing 17 Duration of followup mean 49 pediatric and 64 years mixed was associated with more stricturing and penetrating disease There was no association between mean age of onset and NOD2/CARD15 or either of these with disease behavior These observations were replicated in the mixed cohort Sephardic Jewish origin was inversely correlated with inflammatory behavior P = 0006 independent of NOD2/CARD15 genotype Conclusions Duration of disease and ethnicity irrespective of NOD2/CARD15 genotype and age of onset were the only predictors for penetrating or stricturing disease
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