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Title of Journal: Dig Dis Sci

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Abbravation: Digestive Diseases and Sciences

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Springer US

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DOI

10.1002/ana.410370305

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1573-2568

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The Effects of Combined Treatment of Antioxidants

Authors: Selda GezginciOktayoglu Hasan Basaraner Refiye Yanardag Sehnaz Bolkent
Publish Date: 2008/08/21
Volume: 54, Issue: 3, Pages: 538-546
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Abstract

The aim of this study was to examine whether an antioxidant combination of vitamin C vitamin E and sodium selenate Se has an effect on the liver of diabetic rats Vitamin C vitamin E and Se were administered for 30 days to streptozotocin STZinduced diabetic and control groups In the STZ diabetic group blood glucose levels liver lipid peroxidation LPO and nonenzymatic glycosylation NEG levels increased but blood and liver glutathione levels decreased On the other hand combined antioxidant treatment reversed these effects In the diabetic group some degenerative changes were observed by light and electron microscopic examinations but the degenerative changes decreased in the diabetic group given antioxidant combination Proliferating cell nuclear antigen PCNA immunohistochemistry showed that the number of proliferative hepatocytes increased significantly with antioxidant treatment It was concluded that combined treatment with vitamin C vitamin E and Se has a curative effect against the hepatotoxicity produced by STZinduced diabetes

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