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Title of Journal: Dig Dis Sci

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Abbravation: Digestive Diseases and Sciences

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Springer US

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DOI

10.1016/0378-5122(88)90136-3

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1573-2568

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Clinical Presentation and Disease Phases of Chroni

Authors: YuNan Hsu Calvin Q Pan Ali Abbasi Victor Xia Raghav Bansal KeQin Hu
Publish Date: 2014/02/12
Volume: 59, Issue: 4, Pages: 865-871
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Abstract

The modified normal alanine aminotransferase ALT value ie males 30 and females 19 IU/L is a better criteria associated with histological activity in chronic hepatitis B CHB This study was aimed to assess if the modified ALT criteria could be better associated with disease phases in a cohort of Asian Americans AsAm with CHBThis twocenter retrospective study evaluated 198 nontreated AsAm with CHB and a mean followup of 21 months Both conventional and modified ALT criteria were used to determine the differences and clinical value using modified ALT criteria in classifying CHB phasesAmong HBeAg + patients 293  HBV precore PC and basal core promoter BCP mutations were detected in 244  and 313  respectively Using baseline conventional ALT criteria 97/153 634  patients could be categorized into CHB phases 1 to 4 whereas 56/153 366  were indeterminate Using the modified ALT criteria 43 281  patients had phase changes of which 31/43 721  were moved from phase 1 and indeterminate to phases 2 and 4 more active CHB phases In 13/31 of these patients with liver biopsy 6 194  reported stage 2–4 fibrosis and 10 323  reported grade 1–2 inflammation Using modified ALT criteria to evaluate 48/153 patients with full data at baseline and the end of 1year followup we observed that 19/48 396  changed their CHB phases 5/48 104  moved from phases 1 and 3 to phases 2 and 4 2/48 42  remained in the active phases 10/48 208  became indeterminateDr KeQin Hu has received research or educational grants from Gilead Bristol Myers Squibb Genentech and Merck He also serves as speaker bureau for Gilead Bristol Myers Squibb Genentech and Merck Dr Calvin Q Pan has received research grants from Gilead Bristol Myers Squibb Novartis and Roche He also serves as a consultant advisor and speakers bureau for Gilead and Bristol Myers Squibb

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Other Papers In This Journal:
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  2. Response to Peginterferon-alfa 2b and Ribavirin in Japanese Patients with Chronic Hepatitis C Genotype 2
  3. Correlations of C-reactive Protein Levels and Erythrocyte Sedimentation Rates with Endoscopic Activity Indices in Patients with Ulcerative Colitis
  4. Preprocedural Rabeprazole Treatment Before Endoscopic Submucosal Dissection for Gastric Neoplasms
  5. Do We Need Multiple Biopsies for Assessing Gastric Cancer Risk?
  6. The Pathogenesis of Eosinophilic Esophagitis: Beyond the Eosinophil
  7. Disease Behavior in Children with Crohn’s Disease: The Effect of Disease Duration, Ethnicity, Genotype, and Phenotype
  8. Triggering for Submaximal Exercise Level in Gastric Exercise Tonometry: Serial Lactate, Heart Rate, or Respiratory Quotient?
  9. The Correlation Between the Subsets of Tumor Infiltrating Memory T Cells and the Expression of Indoleamine 2,3-Dioxygenase in Gastric Cancer
  10. Bacterial Translocation to Mesenteric Lymph Nodes Increases in Chronic Portal Hypertensive Rats
  11. Narrow-Banding Images and Structures of Microvessels of Colonic Lesions
  12. Inflammatory Bowel Disease: A Patient’s and Caregiver’s Perspective
  13. Atorvastatin Does Not Improve Liver Biochemistries or Mayo Risk Score in Primary Biliary Cirrhosis
  14. Effective Intra-Esophageal Acid Control Is Associated with Improved Radiofrequency Ablation Outcomes in Barrett’s Esophagus
  15. Effective Intra-Esophageal Acid Control Is Associated with Improved Radiofrequency Ablation Outcomes in Barrett’s Esophagus
  16. The Risk of Colorectal Cancer in Patients with Ulcerative Colitis
  17. Needle Size Has Only a Limited Effect on Outcomes in EUS-Guided Fine Needle Aspiration: A Systematic Review and Meta-Analysis
  18. Are the Echogenicities on Intraductal Ultrasonography Really Biliary Microlithiasis?
  19. The Role of Chromoendoscopy in the Surveillance of the Duodenum of Patients with Familial Adenomatous Polyposis
  20. Gene Expression Profile Analysis of the Spontaneous Reversal of Rat Hepatic Fibrosis by cDNA Microarray
  21. Toll-like Receptor 2 (TLR) −196 to 174del Polymorphism in Gastro-duodenal Diseases in Japanese Population
  22. Bifidobacterial Diversity Determined by Culturing and by 16S rDNA Sequence Analysis in Feces and Mucosa from Ten Healthy Spanish Adults
  23. MRI Prediction of Islet Yield for Autologous Transplantation After Total Pancreatectomy for Chronic Pancreatitis
  24. Targeting an Early and Substantial Increase in Mean Arterial Pressure Is Critical in the Management of Type 1 Hepatorenal Syndrome: A Combined Retrospective and Pilot Study
  25. Liver Transplantation, Liver Resection, and Transarterial Chemoembolization for Hepatocellular Carcinoma in Cirrhosis: Which Is the Best Oncological Approach?
  26. Proximal and Overall Gastric Emptying of Solids in Patients with Reduced Gastric Volume Accommodation Compared to Matched Controls
  27. α-Lipoic Acid Prevents the Induction of iNOS Gene Expression Through Destabilization of Its mRNA in Proinflammatory Cytokine-Stimulated Hepatocytes
  28. A High Level of TM4SF5 Is Associated with Human Esophageal Cancer Progression and Poor Patient Survival
  29. Disrupted Circadian Rhythmicity of the Intestinal Glucose Transporter SGLT1 in Zucker Diabetic Fatty Rats
  30. A High Level of TM4SF5 Is Associated with Human Esophageal Cancer Progression and Poor Patient Survival
  31. Is BRAF Mutation Associated with Interval Colorectal Cancers?
  32. Acute and Acute Severe (Fulminant) Autoimmune Hepatitis
  33. Hepatic Subcapsular Hematoma Secondary to Intrahepatic Pseudoaneurysm Following Cholecystectomy
  34. Protective Effects of Baicalin and Octreotide on Multiple Organ Injury in Severe Acute Pancreatitis
  35. The Neutrophil Respiratory Burst and Bacterial Digestion in Crohn’s Disease
  36. Evaluation of a Non-invasive Method to Detect Cytomegalovirus (CMV)-DNA in Stool Samples of Patients with Inflammatory Bowel Disease (IBD): A Pilot Study
  37. Pleiotrophin Expression in Human Pancreatic Cancer and Its Correlation with Clinicopathological Features, Perineural Invasion, and Prognosis
  38. Endoscopic Management of Large (≥2 cm) Non-pedunculated Colorectal Polyps: Impact of Polyp Morphology on Outcomes
  39. A Meta-Analysis of Antibiotic Therapy for Active Ulcerative Colitis
  40. The Diagnostic Yield of Repeated Endoscopic Evaluation in Patients with Gastrointestinal Bleeding and Left Ventricular Assist Devices
  41. Genes Regulated by Nkx2-3 in Sporadic and Inflammatory Bowel Disease-Associated Colorectal Cancer Cell Lines
  42. Pain and Opioid Use in Chronic Liver Disease
  43. Phytic Acid Modulates In Vitro IL-8 and IL-6 Release from Colonic Epithelial Cells Stimulated with LPS and IL-1β
  44. Refractory Autoimmune Hepatitis: Beyond Standard Therapy
  45. Marked Decrease of Serum Ca 125 Levels After Denver Shunt Placement in a Patient With Cirrhosis and Refractory Ascites
  46. Epstein–Barr Virus-Associated Gastritis: A Case Report
  47. Variability of Oxygenation in Possible Hepatopulmonary Syndrome: Effects of Requiring Two Abnormal Arterial Blood Gas Results for Diagnosis
  48. Lower Serum Level of Adiponectin Is Associated with Increased Risk of Endoscopic Erosive Gastritis
  49. Tight Junction Ultrastructure Alterations in a Mouse Model of Enteral Nutrient Deprivation
  50. Wireless Video Capsule Enteroscopy in Preclinical Studies: Methodical Design of Its Applicability in Experimental Pigs
  51. Do Automated Telephone Systems Decrease Hospital Readmissions Among Patients with Cirrhosis?
  52. Postinfantile Giant Cell Hepatitis Due to Hepatitis E Virus Along with the Presence of Autoantibodies
  53. Acid-Suppressive Effect of Rabeprazole 5 mg and 10 mg Once Daily by 24-Hour Esophageal pH Monitoring in Patients with Non-erosive Reflux Disease in Japan: A Multicenter, Randomized, Parallel-Group, Double-Blind Pharmacodynamic Study
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  55. The Role of Hepatic Ischemia–Reperfusion Injury and Liver Parenchymal Quality on Cancer Recurrence
  56. Hospitalization for Achalasia in the United States 1997–2006
  57. Transjugular Intrahepatic Portosystemic Shunt with Thrombectomy for the Treatment of Portal Vein Thrombosis After Liver Transplantation
  58. Lack of Impact on Polyp Detection by Fellow Involvement During Colonoscopy: A Meta-Analysis
  59. Quantitative Differences Between Primary and Secondary Peristaltic Contractions of the Esophagus
  60. Lack of Impact on Polyp Detection by Fellow Involvement During Colonoscopy: A Meta-Analysis
  61. Comparison of the Outcomes of Endoscopic Ultrasound Based on Community Hospital Versus Tertiary Academic Center Settings
  62. An Evaluation of Adult Electrogastrography Criteria in Healthy Children
  63. Circulating Methylated MINT2 Promoter DNA Is a Potential Poor Prognostic Factor in Gastric Cancer
  64. Predictors of Colorectal Cancer Following a Negative Colonoscopy in the Medicare Population
  65. Testing Beneficial Therapy in Human Cirrhosis Using Animal Models of Cirrhosis
  66. The Biodurability of Covering Materials for Metallic Stents in a Bile Flow Phantom
  67. Factors Predictive of Adverse Events Following Endoscopic Papillary Large Balloon Dilation: Results from a Multicenter Series
  68. Efficacy and Safety of Prucalopride in Chronic Constipation: An Integrated Analysis of Six Randomized, Controlled Clinical Trials
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  73. Enterocutaneous Fistula and Small Bowel Evisceration of Twenty-five Years’ Duration: Successful Surgical and Nutritional Management
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  76. Screening Prevalence and Incidence of Colorectal Cancer Among American Indian/Alaskan Natives in the Indian Health Service
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