Authors: Khalid M Khan Chirag S Desai Bobby Kalb Charmi Patel Brianna M Grigsby Tun Jie Rainer W G Gruessner Horacio RodriguezRilo
Publish Date: 2012/10/21
Volume: 58, Issue: 4, Pages: 1116-1124
Abstract
The relationship between magnetic resonance imaging MRI histopathology and islet yield was examined for chronic pancreatitis patients undergoing total pancreatectomy and autologous islet cell transplant TPAIT to determine if the yield can be predicted by preoperative MRITwenty patients 14 female mean age 4020 ± 125 years range 19–63 underwent MRI before TPAIT mean 3724 ± 891 islet equivalents/kg body weight median 2970 range 76–17770 were procured There was no correlation between islet cell numbers and pancreas weight HgbA1c or cpeptide The most common MRI sequence abnormality was the delayed interstitial phase 14/18 78 The other common MRI sequence abnormalities were precontrast T1W 3D GRE sequence 13/19 68 and the arterial perfusion phase 11/18 61 The pancreatic duct was dilated in 10/20 50 Parenchymal atrophy was noted in 10/20 50 Median scores for individual MRI sequences were greater in patients with an islet cell yield of ≤2500 islet equivalents/kg for the delayed interstitial phase the difference was significant median 25 range 1–3 versus median 05 range 0–3 P = 0034 Histologically the most common feature was fibrosis 17/17 100 the score for fibrosis was greater for patients with an islet cell yield of ≤2500 islet equivalents/kg median 60 range 5–7 versus median 40 range 3–7 P = 0024
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