Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: Dig Dis Sci

Search In Journal Title:

Abbravation: Digestive Diseases and Sciences

Search In Journal Abbravation:

Publisher

Springer US

Search In Publisher:

DOI

10.1007/978-3-319-49682-5_13

Search In DOI:

ISSN

1573-2568

Search In ISSN:
Search In Title Of Papers:

Analysis of the GenomeWide DNA Methylation Profil

Authors: JingMing Zhai XiaoYu Yin Xun Hou XiaoYi Hao JianPeng Cai LiJian Liang LongJuan Zhang
Publish Date: 2013/04/27
Volume: 58, Issue: 7, Pages: 1934-1947
PDF Link

Abstract

To investigate the genomewide DNA methylation profile of side population SP cells of HCC a special subpopulation of cells enriched with cancer stem cells by DNA methylation microarray analysis and to analyze the functions and signal pathways of the aberrantly methylated genes in SP cellsSide population cells were isolated from HCC cell lines Huh7 and PLC/PRF/5 using flow cytometry and the tumorigenicity of these SP cells was assessed in NOD/SCID mice The genomewide DNA methylation status of SP cells and nonSP NSP cells was detected and compared by DNA methylation microarray analysis Genes with differential methylation between SP and NSP cells were further analyzed for their functions and roles in related signaling pathwaysSubcutaneous inoculation of 1 × 103 SP cells yielded tumors in 60  NOD/SCID mice whereas no tumor was developed after the inoculation of 1 × 106 NSP cells Genomewide DNA methylation microarray analysis showed that 72 and 181 genes were hypermethylated and hypomethylated respectively in both Huh7 and PLC/PRF/5 SP cells as compared with their corresponding NSP cells Analyses of signaling pathways revealed that hypermethylated and hypomethylated genes were related to four and eight pathways respectivelyHepatocellular carcinoma SP cells possessed a differential DNA methylation status compared with NSP cells and the differentially methylated genes in SP cells were involved in 12 signaling pathways Our results provide valuable clues for further investigations in elucidating the importance of epigenetic regulation in sustaining HCC SP cells and tumorigenesis

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Increased Numbers of Circulating ICOS + Follicular Helper T and CD38 + Plasma Cells in Patients with Newly Diagnosed Primary Biliary Cirrhosis
  2. Response to Peginterferon-alfa 2b and Ribavirin in Japanese Patients with Chronic Hepatitis C Genotype 2
  3. Correlations of C-reactive Protein Levels and Erythrocyte Sedimentation Rates with Endoscopic Activity Indices in Patients with Ulcerative Colitis
  4. Preprocedural Rabeprazole Treatment Before Endoscopic Submucosal Dissection for Gastric Neoplasms
  5. Do We Need Multiple Biopsies for Assessing Gastric Cancer Risk?
  6. The Pathogenesis of Eosinophilic Esophagitis: Beyond the Eosinophil
  7. Disease Behavior in Children with Crohn’s Disease: The Effect of Disease Duration, Ethnicity, Genotype, and Phenotype
  8. Triggering for Submaximal Exercise Level in Gastric Exercise Tonometry: Serial Lactate, Heart Rate, or Respiratory Quotient?
  9. The Correlation Between the Subsets of Tumor Infiltrating Memory T Cells and the Expression of Indoleamine 2,3-Dioxygenase in Gastric Cancer
  10. Bacterial Translocation to Mesenteric Lymph Nodes Increases in Chronic Portal Hypertensive Rats
  11. Narrow-Banding Images and Structures of Microvessels of Colonic Lesions
  12. Inflammatory Bowel Disease: A Patient’s and Caregiver’s Perspective
  13. Atorvastatin Does Not Improve Liver Biochemistries or Mayo Risk Score in Primary Biliary Cirrhosis
  14. Effective Intra-Esophageal Acid Control Is Associated with Improved Radiofrequency Ablation Outcomes in Barrett’s Esophagus
  15. Effective Intra-Esophageal Acid Control Is Associated with Improved Radiofrequency Ablation Outcomes in Barrett’s Esophagus
  16. The Risk of Colorectal Cancer in Patients with Ulcerative Colitis
  17. Needle Size Has Only a Limited Effect on Outcomes in EUS-Guided Fine Needle Aspiration: A Systematic Review and Meta-Analysis
  18. Are the Echogenicities on Intraductal Ultrasonography Really Biliary Microlithiasis?
  19. The Role of Chromoendoscopy in the Surveillance of the Duodenum of Patients with Familial Adenomatous Polyposis
  20. Gene Expression Profile Analysis of the Spontaneous Reversal of Rat Hepatic Fibrosis by cDNA Microarray
  21. Toll-like Receptor 2 (TLR) −196 to 174del Polymorphism in Gastro-duodenal Diseases in Japanese Population
  22. Bifidobacterial Diversity Determined by Culturing and by 16S rDNA Sequence Analysis in Feces and Mucosa from Ten Healthy Spanish Adults
  23. MRI Prediction of Islet Yield for Autologous Transplantation After Total Pancreatectomy for Chronic Pancreatitis
  24. Targeting an Early and Substantial Increase in Mean Arterial Pressure Is Critical in the Management of Type 1 Hepatorenal Syndrome: A Combined Retrospective and Pilot Study
  25. Liver Transplantation, Liver Resection, and Transarterial Chemoembolization for Hepatocellular Carcinoma in Cirrhosis: Which Is the Best Oncological Approach?
  26. Proximal and Overall Gastric Emptying of Solids in Patients with Reduced Gastric Volume Accommodation Compared to Matched Controls
  27. α-Lipoic Acid Prevents the Induction of iNOS Gene Expression Through Destabilization of Its mRNA in Proinflammatory Cytokine-Stimulated Hepatocytes
  28. A High Level of TM4SF5 Is Associated with Human Esophageal Cancer Progression and Poor Patient Survival
  29. Disrupted Circadian Rhythmicity of the Intestinal Glucose Transporter SGLT1 in Zucker Diabetic Fatty Rats
  30. A High Level of TM4SF5 Is Associated with Human Esophageal Cancer Progression and Poor Patient Survival
  31. Is BRAF Mutation Associated with Interval Colorectal Cancers?
  32. Acute and Acute Severe (Fulminant) Autoimmune Hepatitis
  33. Hepatic Subcapsular Hematoma Secondary to Intrahepatic Pseudoaneurysm Following Cholecystectomy
  34. Protective Effects of Baicalin and Octreotide on Multiple Organ Injury in Severe Acute Pancreatitis
  35. The Neutrophil Respiratory Burst and Bacterial Digestion in Crohn’s Disease
  36. Evaluation of a Non-invasive Method to Detect Cytomegalovirus (CMV)-DNA in Stool Samples of Patients with Inflammatory Bowel Disease (IBD): A Pilot Study
  37. Pleiotrophin Expression in Human Pancreatic Cancer and Its Correlation with Clinicopathological Features, Perineural Invasion, and Prognosis
  38. Endoscopic Management of Large (≥2 cm) Non-pedunculated Colorectal Polyps: Impact of Polyp Morphology on Outcomes
  39. A Meta-Analysis of Antibiotic Therapy for Active Ulcerative Colitis
  40. The Diagnostic Yield of Repeated Endoscopic Evaluation in Patients with Gastrointestinal Bleeding and Left Ventricular Assist Devices
  41. Genes Regulated by Nkx2-3 in Sporadic and Inflammatory Bowel Disease-Associated Colorectal Cancer Cell Lines
  42. Pain and Opioid Use in Chronic Liver Disease
  43. Phytic Acid Modulates In Vitro IL-8 and IL-6 Release from Colonic Epithelial Cells Stimulated with LPS and IL-1β
  44. Refractory Autoimmune Hepatitis: Beyond Standard Therapy
  45. Marked Decrease of Serum Ca 125 Levels After Denver Shunt Placement in a Patient With Cirrhosis and Refractory Ascites
  46. Epstein–Barr Virus-Associated Gastritis: A Case Report
  47. Variability of Oxygenation in Possible Hepatopulmonary Syndrome: Effects of Requiring Two Abnormal Arterial Blood Gas Results for Diagnosis
  48. Lower Serum Level of Adiponectin Is Associated with Increased Risk of Endoscopic Erosive Gastritis
  49. Tight Junction Ultrastructure Alterations in a Mouse Model of Enteral Nutrient Deprivation
  50. Wireless Video Capsule Enteroscopy in Preclinical Studies: Methodical Design of Its Applicability in Experimental Pigs
  51. Do Automated Telephone Systems Decrease Hospital Readmissions Among Patients with Cirrhosis?
  52. Postinfantile Giant Cell Hepatitis Due to Hepatitis E Virus Along with the Presence of Autoantibodies
  53. Acid-Suppressive Effect of Rabeprazole 5 mg and 10 mg Once Daily by 24-Hour Esophageal pH Monitoring in Patients with Non-erosive Reflux Disease in Japan: A Multicenter, Randomized, Parallel-Group, Double-Blind Pharmacodynamic Study
  54. Helicobacter pylori Clarithromycin Resistance and Treatment Failure Are Common in the USA
  55. The Role of Hepatic Ischemia–Reperfusion Injury and Liver Parenchymal Quality on Cancer Recurrence
  56. Hospitalization for Achalasia in the United States 1997–2006
  57. Transjugular Intrahepatic Portosystemic Shunt with Thrombectomy for the Treatment of Portal Vein Thrombosis After Liver Transplantation
  58. Lack of Impact on Polyp Detection by Fellow Involvement During Colonoscopy: A Meta-Analysis
  59. Quantitative Differences Between Primary and Secondary Peristaltic Contractions of the Esophagus
  60. Lack of Impact on Polyp Detection by Fellow Involvement During Colonoscopy: A Meta-Analysis
  61. Comparison of the Outcomes of Endoscopic Ultrasound Based on Community Hospital Versus Tertiary Academic Center Settings
  62. An Evaluation of Adult Electrogastrography Criteria in Healthy Children
  63. Circulating Methylated MINT2 Promoter DNA Is a Potential Poor Prognostic Factor in Gastric Cancer
  64. Predictors of Colorectal Cancer Following a Negative Colonoscopy in the Medicare Population
  65. Testing Beneficial Therapy in Human Cirrhosis Using Animal Models of Cirrhosis
  66. The Biodurability of Covering Materials for Metallic Stents in a Bile Flow Phantom
  67. Factors Predictive of Adverse Events Following Endoscopic Papillary Large Balloon Dilation: Results from a Multicenter Series
  68. Efficacy and Safety of Prucalopride in Chronic Constipation: An Integrated Analysis of Six Randomized, Controlled Clinical Trials
  69. Response to Hepatitis A and B Vaccine Alone or in Combination in Patients with Chronic Hepatitis C Virus and Advanced Fibrosis
  70. Endoscopic Ultrasound-Guided Fine-Needle Aspiration for Duodenal Obstruction Without a Discrete Mass
  71. Capsule Studies Performed in a Tertiary Care Center Versus Community Referrals Prior to Single-Balloon Enteroscopy: Does It Matter?
  72. Equivalent Outcomes After Anatomical and Non-anatomical Resection of Small Hepatocellular Carcinoma in Patients with Preserved Liver Function
  73. Enterocutaneous Fistula and Small Bowel Evisceration of Twenty-five Years’ Duration: Successful Surgical and Nutritional Management
  74. Molecular Mechanisms Elucidating Why Old Stomach Is More Vulnerable to Indomethacin-Induced Damage than Young Stomach
  75. The Effects of Combined Treatment of Antioxidants on the Liver Injury in STZ Diabetic Rats
  76. Screening Prevalence and Incidence of Colorectal Cancer Among American Indian/Alaskan Natives in the Indian Health Service
  77. Hydrogen Peroxide in Upper Gastrointestinal Bleeding: A Coming of Age?
  78. Expressional and Mutational Analysis of Pro-apoptotic Bcl-2 Member PUMA in Hepatocellular Carcinomas
  79. Pharmacokinetics and Tolerability of Intravenous Sildenafil in Two Subjects with Child–Turcotte–Pugh Class C Cirrhosis and Renal Dysfunction
  80. Zero-Inflated Models for Identifying Relationships Between Body Mass Index and Gastroesophageal Reflux Symptoms: A Nationwide Population-Based Study in China
  81. Identification of Patients with Non-D, Non-C Irritable Bowel Syndrome and Treatment with Renzapride: An Exploratory, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial
  82. Airway Management During Upper GI Endoscopic Procedures: State of the Art Review
  83. White Opaque Substance Visualized Using Magnifying Endoscopy with Narrow-Band Imaging in Colorectal Epithelial Neoplasms
  84. The Effect on Gastric Tone of Gastric Electrical Stimulation with Trains of Short Pulses Varies with Sites and Stimulation Conditions
  85. Sessile Serrated Adenomas: Why Conventional Endoscopy Is Okay for Unconventional Polyps
  86. Risk Factors for Complications of Percutaneous Endoscopic Gastrostomy
  87. Defining Virologic Relapse in Chronic Hepatitis B
  88. Pseudomyxoma Peritonei Masquerading As Ascites Secondary to Alcoholic Cirrhosis
  89. A Meta-Analysis of Nucleos(t)ide Analogues in Patients with Decompensated Cirrhosis Due to Hepatitis B
  90. Understanding Liver Health Using the National Center for Health Statistics
  91. Prognostic Factors and Postoperative Recurrence of Calculus Following Small-Incision Sphincterotomy with Papillary Balloon Dilation for the Treatment of Intractable Choledocholithiasis: A 72-Month Follow-Up Study
  92. Finding Sessile Serrated Adenomas: Is It Possible to Identify Them During Conventional Colonoscopy?
  93. Empiric Dilation in Non-obstructive Dysphagia
  94. Clinical Presentation and Disease Phases of Chronic Hepatitis B Using Conventional Versus Modified ALT Criteria in Asian Americans
  95. Aryl Hydrocarbon Receptor Activation Down-Regulates IL-7 and Reduces Inflammation in a Mouse Model of DSS-Induced Colitis
  96. Hospitalized Patients with Cirrhosis Should Be Screened for Clostridium difficile Colitis
  97. Helicobacter pylori Infection and Gender: A Meta-Analysis of Population-Based Prevalence Surveys
  98. Duodenal Gastrointestinal Stromal Tumor Adjacent to the Minor Papilla with Concomitant Pancreatic Divisum
  99. Fecal Human β-Defensin 2 in Children with Cystic Fibrosis: Is There a Diminished Intestinal Innate Immune Response?
  100. Pharmacogenetics of the Effects of Colesevelam on Colonic Transit in Irritable Bowel Syndrome with Diarrhea
  101. Fucosylated Fraction of Alpha-Fetoprotein as a Predictor of Prognosis in Patients with Hepatocellular Carcinoma After Curative Treatment
Search Result: