Authors: Donghua Liao Anne Lund Krarup Flemming Holbæk Lundager Asbjørn Mohr Drewes Hans Gregersen
Publish Date: 2014/02/28
Volume: 59, Issue: 8, Pages: 1810-1816
Abstract
Differences in contraction characteristics between primary and secondary peristalsis have only been scarcely studied Recently new measures of contractile activity in the human esophagus were developed The study aims were to use combined manometry and impedance planimetry pressurecrosssectional area PCSA recordings from healthy volunteers to examine esophageal peristalsis and furthermore to investigate the effect of the motility enhancing drug erythromycin to study differential effects on the two types of contractionsSixteen healthy volunteers participated in the study mean age 23 range 19–34 years 6 females An esophageal probe with a bag for CSA measurement was positioned 10 cm above the lower esophageal sphincter Bag volume was increased stepwise from 5 to 25 ml before and after intravenous infusion of 250 mg erythromycin Swallowevoked primary and distensionevoked secondary esophageal peristalsis were compared with regard to 1 pressure amplitude 2 CSA amplitude 3 preload tension wall tension before an evoked contraction 4 contractile tension and 5 work outputsPrimary peristalsis induced more efficient contractions as the contraction amplitudes work output and contractile tension were higher compared to secondary peristalsis P 0001 Erythromycin induced change in CSA during distensionevoked secondary peristalsis CSA before 2129 ± 268 vs after 1805 ± 233 P 005 The sensitivity to esophageal distension increased with the distending volume both before and during erythromycin The sensitivity was not changed by erythromycin P = 06
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