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Title of Journal: Dig Dis Sci

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Abbravation: Digestive Diseases and Sciences

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Springer US

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DOI

10.1016/0001-6160(75)90191-1

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1573-2568

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The Risk of Colorectal Cancer in Patients with Ulc

Authors: Tobias M Nowacki Markus Brückner Maria Eveslage Phil Tepasse Friederike Pott Nils H Thoennissen Karin Hengst Matthias Ross Dominik Bettenworth
Publish Date: 2014/10/04
Volume: 60, Issue: 2, Pages: 492-501
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Abstract

Ulcerative colitis increases the risk of developing dysplasia and colitisassociated cancer CAC The purpose of this study was to determine the risk factors as well as protective measures for disease burden need for colectomy and the development of CAC in ulcerative colitis UC patientsA cohort of n = 434 UC patients was evaluated Data analysis was performed by univariate and multivariate logistic regression Odds ratios OR and 95  confidence intervals CI were calculated and significance was assessed by the likelihood ratio testMean patient age at UC diagnosis was 457 ± 151 years which manifested mainly as pancolitis 47  or leftsided colitis 452  CAC was detected in ten patients 23  UC disease duration was strongly associated with the risk of CAC P  00014 disease duration between 9 and 15 years OR of 25 95  CI 02–411 more than 15 years OR of 214 95  CI 26–1736 The risk of developing dysplasia lowgrade intraepithelial neoplasia LGIEN and highgrade intraepithelial neoplasia HGIEN or the need to undergo colectomy was also significantly related to disease duration P = 0006 P = 0002 respectively Established antiinflammatory medication eg 5ASA antiTNFα significantly reduced the risk of both dysplasia and CAC P = 002Despite the use of modern therapies for UC CAC rates remain high In our study risk factors included disease duration while antiinflammatory therapies reduced the risk Effective control of the intestinal inflammation also reduced the disease burden as indicated by decreased risk of requiring colectomy underscoring the need for sufficient surveillance and antiinflammatory therapiesWe thank Faekah Gohar for proofreading the manuscript D Bettenworth was supported by a research fellowship from the Faculty of Medicine Westfälische WilhelmsUniversität Münster M Brückner was supported by a “Gerok” rotational position of the Deutsche Forschungsgemeinschaft DFG SFB1009B8

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